Minolta Company, Ltd.

Mitsubishi Tanabe Pharma Corporation

Welfide Corporation

Tsutomu Yoshikawa

Hiroshi Ochi

Yasuhiro Fujino

Hideki Nagata

Shigeru Sawamura

Koji Naito

Shigeki Kuwahara

Teruaki Imada

Naruyasu Komorita

Fujio Kobayashi

An antibody has an antagonistic effect against IL-33. In particular an isolated human anti-IL-33 neutralizing monoclonal antibody has framework regions with amino acid sequences from a germline, including combinations and fragments of such sequences. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce the foregoing human anti-IL-33 neutralizing monoclonal antibodies having framework regions.

Human anti-IL-33 neutralizing monoclonal antibody

An object of the present invention is to provide an antibody having antagonistic effect against IL-33, in particular an isolated human anti-IL-33 neutralizing monoclonal antibody wherein amino acid sequences of framework regions are amino acid sequences that are amino acid sequences from a germline or a combination of amino acid sequences thereof, or a fragment thereof. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce a human anti-IL-33 neutralizing monoclonal antibody having framework regions comprising amino acid sequences that are amino acid sequences of a germline or a combination of amino acid sequences thereof.

An illuminating apparatus has a light source emitting illumination light; and a prism having a plurality of reflecting surfaces and reflecting the illumination light from said light source by the reflecting surfaces to thereby bend an illumination optical path at an obtuse angle.

Illuminating apparatus, and projector using the illuminating apparatus

IgE antibody production inhibitors and autoimmune diseases inhibitors

A light guide support mechanism to minimize light transmission loss to the extent possible that houses a light guide in hollow cones such that each of the two end surfaces of the light guide protrudes from the windows of cover members fixed to either external end of the pair of hollow cones that are linked along their axis and that suspend the light guide in the empty spaces in the cones in a suspended state by means of relative rotation of the hollow cones such that the ridges of the light guide are in contact with the edges of the windows in the covers in a point-to-surface or edge-to-surface fashion.

Light guide support mechanism and supporting method

Growing community of inventors

Osaka, Japan

Tsutomu Yoshikawa