Fujisawa Pharmaceutical Company, Ltd.

Nissan Chemical Industries Limited

Sk&f Lab Co.

Tsutomu Toyonaka Teraji

Takashi Kamiya

Kazuo Sakane

Jiro Goto

Teruo Kyoto Oku

Masashi Hashimoto

Osamu Nakaguti

Yoshiharu Nakai

Yoshihisa Saito

Youichi Shiokawa

Keiji Hemmi

Yoshinari Sato

Kunihiko Tanaka

Hitoshi Nakamura

Takayuki Namiki

Norihiko Shimazaki

Kazuo Okumura

Eishiro Todo

Toru Takeuchi

Kazushige Kawada

Toshikazu Adachi

Takao Takaya

Hisashi Takasugi

Tadaaki Komori

Yuji Takahashi

Takahiro Furuhashi

Susumu Tahara

Graham J Durant

Yoshio Kawai

Ikuo Ueda

Hiroshi Imanaka

Masanobu Kohsaka

Michio Yamashita

Hiroyuki Setoi

Fumio Shimojo

Itsuo Uchida

Shigetaka Nishino

Yasuo Kamuro

Atsushi Yamamura

Koichi Hirai

Seiichi Fujii

Junji Hosoda

Suita Saito

Teruo Oko

Osamu Nakagati

Keiji Takai

Jiro Gotto

Hideo Yaqi

Shinichi Sugita

Osamu Nakaguit

The present invention relates to aminoarylsulfonic acid-phenol-formaldehyde condensate useful for incorporation into cementing compositions, for example, mortar, cement paste and the like, for improving slumping characteristics.

Aminoarylsulfonic acid-phenol-formaldehyde condensate and concrete

The present invention relates to aminoarylsulfonic acid-phenol-formaldehyde condensate and concrete admixture comprising the same for incorporation in cementing compositions, for example, mortar, cement paste and the like, for improving slumping characteristics.

The present invention discloses a new plant growth regulating composition which comprises, as an active ingredient, a selected succinamide compounds, maleimide compounds, succinic anhydride compounds, maleic anhydride compounds of general formula: ##STR1## if preferably, along with ethephon. In this invention, the plant growth regulating composition has the effect of plant growth controlling activity (herbicidal activity) and an abscission layer forming activity for a fruit harvest aid, and the said plant growth regulating composition does not cause hazards such as defoliation and injuries to the fruit surface, nor does it affect immature fruit, but acts specifically on matured fruit and promptes formation of abscission layer that aids in the separation of matured fruit.

Method for regulating plant growth

The present invention relates to aminoarylsulfonic acid-phenol-formaldehyde condensate and concrete admixture comprising the same for incorporation in cementing composition, for example, concrete, motar, cement paste and the like, for improving slumping characteristics.

A process for producing a 2-cephem or 3-cephem derivative compound of the formula: ##STR1## wherein R.sub.1 represents a substituted or unsubstituted amino radical and R.sub.4 represents hydrogen or a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and the dotted line indicates the alternate bond structure providing 3-cephem or 2-cephem, which comprises:

Disulfide substituted oxazetidine derivatives

The present invention involves certain thiazol-4-yl-acetic acid compounds which are valuable intermediates for the preparation of cephem antibiotics. Said intermediates have the following structure: ##STR1## wherein R.sup.1 is an amino or a protected amino group; R.sup.2 is a group of the formula 13 CONH--R.sup.5 or --NHCO--R.sup.5 wherein R.sup.5 is pyridyl, thiazolyl or an isoxazolyl ring having lower alkyl and halogen substituted phenyl substituents, and A is lower alkylene, or a non-toxic salt thereof.

Thiazolylacetic acid derivative

The invention relates to intermediates useful in the preparation of antimicrobial compounds, the intermediates being of the formula: ##STR1## wherein R.sup.A is --SCN or --S.sup..sym. (R.sup.3).sub.2, wherein

Cephem compounds

The invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is phosphono, dihalophosphoryl, di(lower) alkoxyphosphoryl, O-lower alkylphosphono, diaminophosphoryl, (amino) (hydroxy) phosphoryl or (lower alkoxy) (morpholino) phosphoryl,

Cephem intermediates

The invention relates to a concrete admixture comprising a polyethyleneimine compound for incorporation into a cementing composition.

Concrete admixture

New triazine derivatives represented by the formula: ##STR1## wherein R.sup.1 is hydrogen or halogen;

Triazine derivatives, and pharmaceutical compositions comprising the same

New triazine derivatives represented by the formula: ##STR1## wherein R.sup.1 is aryl, pyridyl, thienyl, 1,2,3,4-tetrahydroquinolyl or 1,3,4,5-tetrahydro-2H-1-benzazepinyl, optionally substituted with lower alkyl, lower alkoxy, halogen, nitro or oxo, R.sup.2 is hydrogen, lower alkyl or carbamoyl substituted with lower alkyl or ar(lower)alkyl, and Z is a group selected from ##STR2## and pharmaceutically acceptable salt thereof, processes for preparation thereof and pharmaceutical compositions comprising the same of antihypertensive and antithrombotic activity.

New triazine derivatives represented by the formula: ##STR1## wherein R.sup.1 is hydrogen; halogen or hydrazinocarbonyl(lower)alkyl;

The present invention relates to new 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antimicrobial activities and to processes for preparation thereof, to pharmaceutical compositions comprising the same, and to a method of using the same therapeutically in the treatment of infectious diseases in humans and animals. This division relates to intermediate compounds, namely amino or amido-thiazolyl, substituted oxyimino disubstituted acetic acid of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;

Amino thiazole compounds

A novel compound, useful as an intermediate in the production of compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sub.a.sup.1 is hydrogen, amino or a protected amino group,

Pyridinyl and pyrimidinyl derivatives

Alkoxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl) acetic acid compounds are intermediates for cephem compounds.

Growing community of inventors

Toyonaka, Japan

Tsutomu Toyonaka Teraji