Other

Kowa Company Limited

Pola Chemical Industries, Inc.

Keio University

Saitama Medical University

Dna Chip Research Inc.

Kayteebio, Co. & Ltd.

Takeuchi, Tsutomu

Yoshimoto, Keiko

Tsuzaka, Kensei

Tsutomu Takeuchi

Keiko Yoshimoto

Yoshiyuki Miyata

Masakazu Sakaguchi

Seiki Kobayashi

Toshimitsu Suzuki

Katsuya Suzuki

Hiroaki Takayanagi

Yumiko Osa

Yumiko Suzuki

Yoko Sato

Kensei Tsuzuka

Kensei Tsuzaka

Yohei Ishizawa

Seiji Nakamura

Koichi Amano

Motohiko Tanino

Yuko Hata

The present invention provides a prophylactic and/or therapeutic agent for inflammatory disease including a compound or a salt thereof, or a solvate thereof, the compound represented by a formula (1): [where each sign is defined as described in the description] as an active ingredient.

Prophylactic and/or therapeutic agent for inflammatory diseases which contains pyrrolopyrimidine compound as active ingredient

A method of screening a novel BAFF suppressor or inhibitor. More specifically speaking, a method which comprises adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell to thereby induce the production of BAFF by the cell; a method of screening a substance capable of suppressing the expression or activity of BAFF which comprises adding a test substance to a BAFF-production system prepared by adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell and measuring the expression amount and/or the activity of BAFF in the BAFF-production system; and a BAFF production inducer for a BAFF-producing cell which contains a combination of TPA with ionomycin and/or an anti-CD3 antibody.

Method of screening baff suppressor or inhibitor

Method of screening Baff suppressor or inhibitor

Dibenzosuberanyl piperazine derivatives represented by the following formula (I):wherein R represents an aliphatic hydrocarbon group, which may contain one or more heteroatom-containing substituent groups and may preferably contain 2 to 30 carbon atoms, and physiologically acceptable salts thereof; and medicinal compositions containing these dibenzosuberanyl piperazine derivatives and/or physiologically acceptable salts thereof. These compounds show effectiveness in allowing resistance-acquired causes of diseases to restore sensitivity to drug, that is, a resistance overcoming effect.

Dibenzosuberanyl piperazine derivatives and drug-resistance overcoming agents containing the derivatives

Disclosed herein is an antiprotozoal composition containing a 2-nitroimidazole derivative as its active component. This drug is especially useful against Trypanosoma cruzi. Process for the preparation is also disclosed.

Antiprotozoal composition containing a 2-nitroimidazole derivative and

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Tokyo, Japan

Tsutomu Takeuchi