Toray Industries, Inc.

Santen Pharmaceutical Co., Ltd.

Tsutomu Suzuki

Hiroshi Nagase

Kuniaki Kawamura

Toshiaki Tanaka

Shiro Mita

Takashi Endo

Takashi Endoh

Koji Oshima

Kimiyasu Shiraki

Hideaki Inada

Tomohiko Suzuki

Kiyoshi Matsuno

Yasushi Kuraishi

The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R, R, R, R, R, R, R, R, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.

Remedies for neuropathic pain and model animals of neuropathic pain

Remedies for drug addiction

A method for preventing or treating drug dependence comprising administering to a human in need thereof a pharmaceutically effective amount of a 1,4-(diphenylalkyl)piperazine compound represented by the following formula &lsqb;I&rsqb; or a pharmaceutically acceptable salt thereof, wherein R is lower alkoxy; R is lower alkoxy; A is lower alkylene and B is lower alkylene;

Therapeutic agents for drug dependence

Growing community of inventors

Yokohama, Japan

Tsutomu Suzuki