Wako Pure Chemical Industries, Inc.

Takeda Chemical Industries, Inc.

Waco Pure Chemical Ind. Inc.

Wada Pure Chemical Ind., Ltd.

Tsutomu Miyagawa

Motoaki Tanaka

Yasuaki Ogawa

Masaki Yamamoto

Hiroaki Okada

Kazuo Shiraki

Toshio Watanabe

Masami Ishihara

Hiroyoshi Nawa

Tsutomu Tani

Hideo Takeuchi

Kazuo Maruhashi

Takashi Nakata

Joji Nagaoka

Kazuhiko Yamashita

Nobuaki Minamii

Masahiko Sugano

4-Halogeno-2-alkoxyimino-3-oxo fatty acid can be produced by one-pot and one-step by reacting a halogenating agent with a 2-alkoxyimino-3-oxo fatty acid ester in an ether solvent or a mixed solvent of an ether solvent and an inert organic solvent such as carbon tetrachloride, benzene, toluene, etc.

Process for producing 4-halogeno-2-alkoxyimino-3-oxo fatty acid

An azo amide compound of the formula .dbd.N--C(CH.sub.3).sub.2 --CO--NH--R].sub.2 or a hydrate thereof or an acid-addition salt thereof, wherein R is --CH.sub.2 CH.dbd.CH.sub.2, benzyl chloride, picolyl, tetrahydropyridylmethyl and N-piperidinoethyl, is useful as a functional polymerization initiator for polymerizing acrylonitrile, methyl acrylate, styrene, vinyl acetate and other vinyl compounds.

Bis-alkylamide azo polymerization initiators

Glycero-phosphatidylcholine is acylated with a higher fatty acid anhydride in the presence of a special organic solvent in the absence of a catalyst.

Novel process for producing phosphatidylcholine derivatives

Cyclic azoamidine compounds having the formula and salts thereof are disclosed. ##STR1## wherein R denotes a methyl group or an ethyl group, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently denote a lower alkyl group having one to four carbon atoms or a hydrogen atoms, provided that a case where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are all hydrogen atoms is excluded. The cyclic azoamidine compounds and their salts are useful as polymerization initiators in the production of polymer compounds.

Azoamidine compounds having a c-alkylated imidazoline ring and salts

The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds each is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer. The thus-obtained high molecular polymer has good aging stability and can be used advantageously as an exipient for pharmaceutical preparations.

Polymer, production and use thereof

A mixture of an isomer of 2,2'-azobis(2,4-dimethylvaleronitrile) having a low melting point in an amount of about 70% by weight or more and an isomer of 2,2'-azobis(2,4-dimethylvaleronitrile) having a high melting point in an amount of about 30% by weight or less shows excellent solvent solubility, which is higher than that of the isomer having a low melting point. The mixture is useful as a polymerization initiator, and also as a blowing agent.

2,2'-Azobis(2,4-dimethylvaleronitrile) isomer mixture predominant in low

The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds each is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer. The thus-obtained molecular polymer has good aging stability and can be used advantageously as an excipient for pharmaceutical preparations.

A polymer or copolymer of lactic acid and/or glycolic acid which has a weight-average molecular weight of not less than about 5,000 and a dispersity of about 1.5 to 2 is advantageously used as a biodegradable polymer or copolymer for medical preparation.

Polymer and its production

A copolymer of lactic acid and glycolic acid which has a weight-average molecular weight of not less than about 5000 and a dispersity of about 1.5 to 2 is advantageously used as a biodegradable polymer for medical preparation.

Copolymer and method for producing the same

Water-soluble polymers having high molecular weight with little branching and good water solubility, particularly acrylamide series polymers having excellent flocculation effect can be obtained when 2,2'-azobis-(N,N'-dimethyleneisobutylamidine) or an acid addition salt thereof or a mixture of 2,2'-azobis(N,N'-dimethyleneisobutylamidine) or an acid addition salt thereof and another azo compound is used as polymerization initiator.

Process for producing water-soluble polymers

Unsymmetrical azonitriles of the formula, ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently straight- or branched-chain alkyl having 1 to 7 carbon atoms or alkoxy substituted straight- or branched-chain alkyl having 2 to 11 carbon atoms but at least one of R.sup.1 and R.sup.2 and at least one of R.sup.3 and R.sup.4 must be different, have good efficiency as initiator for polymerizations or copolymerizations of vinyl monomers. These unsymmetrical azonitriles can be prepared by oxidizing a corresponding unsymmetrical hydrazo compound.

Growing community of inventors

Kawagoe, Japan

Tsutomu Miyagawa