Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Tsutomu Kawata

Seiichi Kobayashi

Osamu Asano

Daniel P Rossignol

William J Christ

Naoyuki Shimomura

Junsaku Nagaoka

Shigeru Souda

Shuhei Miyazawa

Mitsuaki Miyamoto

Tetsuya Kawahara

Kazuo Okano

Shinya Abe

Isao Yamatsu

Hiroyuki Yoshimura

Yoshimasa Machida

Lynn D Hawkins

Koukichi Harada

Kouichi Katayama

Ieharu Hishinuma

Tsutomu Yoshimura

Hiromasa Suzuki

Norihiro Ueda

Takashi Yamanaka

Junichi Nagakawa

Tsuneo Wakabayashi

Kaname Miyamoto

Hidetoshi Kawashima

Naoko Nagaoka

Shigeto Negi

Richard S Clark

Fumihiro Ozaki

Kenji Hayashi

Nobuaki Sato

Manabu Murakami

Akiharu Kajiwara

Nobuhisa Watanabe

Hiroshi Tanaka

Hitoshi Harada

Masanobu Shinoda

Takashi Inoue

Fumiyoshi Matsuura

Itaru Tsukada

Atsushi Kamada

Toshihiko Naito

Makoto Kotake

Toshikazu Shimizu

Taro Terauchi

Nobuyuki Yasuda

Tatsuo Horizoe

Seiji Yoshikawa

Toshiyuki Matsuoka

Isao Tanaka

Yoshimitsu Naoe

Shuichi Suzuki

Akifumi Kimura

Osamu Ito

Motoji Kogushi

Takashi Musha

Hiroe Minami

Naoki Ozeki

Hiroko Kobayashi

Ken-ichi Chiba

Naoto Ono

Kaya Ohashi

Syuhei Miyazawa

Yoshiaki Oohashi

Toyokazu Haga

Hiroshi Akamatsu

Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.

Substituted liposaccharides useful in the treatment and prevention of endotoxemia

A 2-iminoimidazole derivative represented by the formula: {wherein R, Rand Rrepresent hydrogen, optionally substituted Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2013;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc., and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocycle], etc.}or salt thereof.

2-iminoimidazole derivatives (2)

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I);(wherein Rrepresents e.g. an amino group which may be substituted with an alkyl group; Rrepresents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; Rrepresents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.

Condensed imidazole compounds and a therapeutic agent for diabetes mellitus

Substituted liposaccharides useful in the treatment and prevention of

Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection.

Anti-endotoxin compounds

A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##

Glycerin derivative and its pharmacological use

A guanidinobenzoic ester derivative having the formula is novel and effective to inhibit enzymes such as trypsin, plasmin and thrombin, being useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis. ##STR1## wherein X represents a group of the formula: ##STR2## in which Y is a group of the formula: --(CH.sub.2).sub.m --, m being an integer of 2 or 3, ##STR3## or a group of the formula:

Guanidinobenzoic ester derivative

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Waltham, MA, United States of America

Tsutomu Kawata