Nihon Nohyaku Co., Ltd.

Tsutomu Kasai

Hitoshi Kurono

Kuniaki Taninaka

A 1,3-dithiol-2-ylidene malonate derivative having the formula, ##STR1## wherein R.sup.1 and R.sup.2, which may be same or different, represent individually a C.sub.1 -C.sub.4 alkyl group has effects of stimulating, improving and recovering the functions of livers, and can prevent, alleviate and cure various liver damages of humans and animals when administered thereto either orally or parenterally.

Pharmaceutical compositions containing 1,3-dithiol-2-ylidene malonate

A 1,3-dithiolan-2-ylidene malonate derivative having the formula, ##STR1## wherein R.sup.1 and R.sup.2, which may be same or different, represent individually a C.sub.1 -C.sub.4 alkyl group; and R.sup.3 represents a chloromethyl group, a phenyl group, a group of the formula ##STR2## (where R.sup.4 and R.sup.5 represent individually a C.sub.1 -C.sub.4 alkyl group, or may form, in combination, a lower alkylene group which is sometimes intercepted by an oxygen atom), or a group of the formula ##STR3## (where M represents a hydrogen atom or a salt-forming residue; and A represents a lower alkylene group, a lower alkylene group, a phenylene group or a cyclohexenylene group), has effects of stimulating, improving and recovering the functions of livers, and can prevent, alleviate and cure various liver damages of humans and animals when administered thereto either orally or parenterally.

4-Substituted-1,3-dithiolan-2-ylidene malonates and pharmaceutical

A 1,3-dithiolan-2-ylidene malonate derivative having the formula, ##STR1## WHEREIN R.sup.1 and R.sup.2, which may be the same or different, represent individually a C.sub.1 -C.sub.5 alkyl group or a C.sub.1 -C.sub.4 alkoxy-ethyl group; X.sup.1 and X.sup.2, which may be the same or different, represent individually an oxygen or sulfur atom; and n represents 0 or 1, is low in toxicity, has effects of stimulating, improving and recovering the functions of livers, and can prevent, alleviate and cure various liver damages of humans and animals when administered thereto either orally or parenterally.

Pharmaceutical compositions comprising 1,3-dithiolan-2-ylidene malonate

A 1,3-dithiolan-2-ylidene malonate derivative having the formula, ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, represent individually a C.sub.1 -C.sub.4 alkyl group; and R.sup.3 represents a hydrogen atom, an acetyl group or a propionyl group, has effects of stimulating, improving and recovering the functions of livers, and can prevent, alleviate and cure various liver damages of humans and animals when administered thereto either orally or parenterally.

Pharmaceutical compositions containing

A 1,3-dithiolan-2-ylidene malonate derivative having the formula, ##STR1## wherein R.sup.1 and R.sup.2, which may be same or different, represent individually a C.sub.1 -C.sub.4 alkyl group; and R.sup.3 represents a chloromethyl group, a phenyl group, a group of the formula ##STR2## (where R.sup.4 and R.sup.5 represent individually a C.sub.1 -C.sub.4 alkyl group, or may form, in combination, a lower alkylene group which is sometimes intercepted by an oxygen atom), or a group of the formula ##STR3## (where M represents a hydrogen atom or a salt-foming residue; and A represents a lower alkylene group, a lower alkenylene group, a phenylene group or a cyclohexenylene group), has effects of stimulating, improving and recovering the functions of livers, and can prevent, alleviate and cure various liver damages of humans and animals when administered thereto either orally or parenterally.

A compound having the formula, ##STR1## wherein R.sup.1 and R.sup.2, which may be same or different, represent individually a C.sub.1 -C.sub.5 alkyl group; and n represents an integer of 1, 3 or 4, has effects of stimulating, improving and recovering the functions of livers, and can prevent, alleviate and cure various liver damages of humans and animals when administered either orally or parenterally.

Growing community of inventors

Sakai, Japan

Tsutomu Kasai