Fujisawa Pharmaceutical Company, Ltd.

Tsutomu Kaizu

Masanori Okamoto

Hirokazu Tanaka

Masakazu Kobayashi

Hiroshi Kayakiri

Masakuni Okuhara

Hiroshi Hatanaka

Kozo Sawada

Mineo Niwa

Katsuya Nakamura

Eisaku Tsujii

Yoshiko Yokota

Kouichi Tamura

Toshio Hattori

Kiyoshi Takatsuki

Yohsuke Maeda

Monoclonal or polyclonal antibodies capable of recognizing at least one antigenic determinant located on the FR-900506 compound, are disclosed. FR-900506 is a compound having pharmacological activities such as immunosuppressive activity and antimicrobial activity, and has the following structure: ##STR1## Also disclosed are enzyme immunoassays for FR-900506 based on the antibodies of the invention and test kits for detection of FR-900506. A process for preparing a monoclonal antibody which selectively binds to FR-900506 is also disclosed.

Anti-FR-900506 substance antibodies and highly-sensitive enzyme

Pyrroline compounds of the formulae (I) and (II) are effective in the treatment of retroviral infection and lymphadenopathy. ##STR1##

Antiretroviral agent, method of use thereas, and method of preparation

The invention relates to a compound of antimicrobial activity of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkanoyl,

Compound, WF11605 and derivative thereof

Growing community of inventors

Tsukuba, Japan

Tsutomu Kaizu