Other

Daikin Industries, Ltd.

Kyoto University

Taisho Pharmaceutical Co., Ltd.

Adeka Argus Chemical Co., Ltd.

Yasunori Nishijima & Daikin Industries Ltd.

Tsutomu Kagiya

Kazuhiro Shimokawa

Toru Yoshizawa

Yorisato Hisanaga

Seiichi Nishimoto

Mitsuyuki Abe

Yuta Shibamoto

Tatsuo Nakada

Motonobu Minagawa

Yutaka Nakahara

Tohru Tanami

Tsuneo Tsubakimoto

Hironobu Murase

Ryoji Kimura

Susumu Otomo

Ryoichi Oshiumi

Ludmila Mihailovna Volkova

Nataliya Yurievna Lugovskaya

Koichi Sakano

Nina Petrovna Konovalova

Lubov Sergeevna Vasilieva

An ameliorating agent for cancer chemotherapy is disclosed, which comprises a chromanol glycoside represented by the following general formula (1) (wherein R, R, R, and R, which are identical or different from each other, stand for a hydrogen atom or a lower alkyl group, Rstands for a hydrogen atom, a lower alkyl group, or a lower acyl group, X stands for a monosaccharide residue or an oligosaccharide residue optionally having the hydrogen atom of the hydroxyl group in the saccharide residue substituted with a lower alkyl group or a lower acyl group, n is an integer in the range of 0-6, and m is an integer in the range of 1-6). According to this invention, a novel ameliorating agent for cancer chemotherapy is provided which acts safely and effectively in a small dosage to enhance the carcinostatic action of an anti-cancer agent in cancer chemotherapy and repressing side effects by cancer chemotherapy as well.

Ameliorant for chemical treatment of cancer

A 2-nitroimidazole compound of the formula: ##STR1## wherein R.sub.f is a fluorine-containing organic group which has at least one fluorine atom on a carbon atom which bonds to the nitrogen atom of the imidazole ring or a carbon atom which bonds to said carbon atom and a radiosensitizer comprising said nitroimidazole derivative.

Fluorine-containing nitroimidazole compounds

A 2-nitroimidazole derivative of the formula: ##STR1## wherein R.sub.f is a group of the following formula (II) or (III):

Fluorine-containing 2-nitroimidazole derivatives

Fluorine-containing nitroazole derivatives and radiosensitizer

A radiation sensitizer of the present invention contains a particular nitrotriazole compound as an active ingredient and accelerates inactivation of intractable hypoxic cells in a malignant tumor by irradiation.

Radiation sensitizer

Growing community of inventors

Kyoto, Japan

Tsutomu Kagiya