Jasco Corporation

Nippon Soda Co., Ltd.

Other

Fujifilm Corporation

Mitsubishi Denki Kabushiki Kaisha

Hoechst Japan Limited

Koichi Shudo

Tobishi Yakuhin Kogyo Kabushiki Kaisha

Fuji Yakuhin Co., Ltd

Tsutomu Inoue

Yoshihito Narita

Takashi Inaba

Mizuho Inazu

Fuminori Sato

Isao Umezawa

Masayuki Yuasa

Kazuyuki Kitamura

Hiroyoshi Hidaka

Toshiya Inubushi

Tatsuo Sugioka

Tadashi Morita

Osamu Sakuma

Tomohiko Ishikawa

Hideyuki Tanaka

Masaya Akashi

Tadashi Toshioka

Masatoshi Hagiwara

Hirohito Oooka

Kento Aizawa

Kenji Naitoh

Hiroshi Nakamura

Koji Matsumoto

Takeshi Ohkuma

Yasushi Kubota

Noriyoshi Arai

Takashi Iwanaga

Naoki Ashizawa

Masateru Usuki

Akira Endo

Hans-Jochen Lang

Koji Saito

Takahiro Sato

Hiroshi Kitagawa

Yoshiro Kitamura

Denis Carniato

Heinrich Christian Englert

Motoichi Ohtsu

Hiroyuki Nakano

Yoshiko Kubo

Tadashi Sugiura

Shuji Mononobe

Isamu Kasahara

Junichiro Uda

Yoshikazu Ito

Osamu Nagata

Masaya Nagase

Hirohito Ooka

Toshiharu Saiki

Shigeyuki Kimura

Sachiho Miyata

Masakazu Katoh

Seiichi Kobashi

Ryoichi Satoh

Takeo Soejima

Mutsumi Senuma

Susumu Teruyama

Daisuke Dogomi

Soichi Kaneda

Tohru Sakamaki

Norihito Hujiwara

Eiji Katayama

Daisuke Sato

Naofumi Watanabe

Tomomitsu Sasaki

Shizumasa Yokota

Yumi Yajima

Kenji Naito

Shinpei Kidokoro

Horoyoshi Hidaka

Tetsuya Taniguchi

An information processing device detects a cell candidate region for determining a unity of a cell from a vessel image obtained by imaging a vessel in which the cell is seeded and includes at least one processor. The processor performs an acquisition process of acquiring the vessel image, performs a detection process of detecting a cell region including the cell and a cell-like region including an object similar to the cell as the cell candidate regions from the acquired vessel image, and an output process of outputting information indicating the detected cell candidate regions.

Information processing device, information processing method, and program

An Attenuated total reflection measuring apparatus capable of Raman spectral measurement has an infrared optical instrument and a Raman module. The infrared optical instrument is disposed on an ATR prism side of a sample, and is provided to irradiate the ATR prism with an infrared light, and collect the infrared light from the ATR prism. The Raman module is disposed on a side opposite to the ATR prism side relative to the sample, and has a guide tube that outputs an excitation light from an excitation light source to the sample, and a lens portion disposed inside thereof. An end of the guide tube is in a position to push the sample to the ATR prism. The Raman module has a lens position adjustment mechanism that moves the lens portion along an optical axis, and a spectroscope that detects a Raman scattering light collected by the lens portion.

Attenuated total reflection measuring apparatus capable of Raman spectral measurement

A filter unit for a Raman microscope mounted with a dark-field objective lens unit includes a frame body, a plurality of UV-LED elements that is disposed around a window part of the frame body to emit UV light, and a long-pass filter that is supported to the frame body to cover the window part of the frame body and transmits a light having a wavelength longer than the wavelength of the UV light. The filter unit has a dark-field UV irradiation function, and is able to impart a fluorescence observation function to the Raman microscope.

Raman microscope having fluorescence observation function and filter unit

To provide a microspectroscope that can perform a wide range mapping measurement with high sensitivity, at high speed, and with high wavelength resolution. The Raman spectroscope comprises: a unit for linearly irradiating excitation light; a movable stage for a sample; an objective lens for focusing Raman light from the linear irradiation region; an incident slit provided at the imaging position of Raman light; a spectrometer for diffusing the passing light; a CCD detector for detecting Raman spectral image; and a control device for controlling the mapping measurement by synchronizing the movable stage and the CCD detector. The control device controls the movable stage to move in the direction orthogonal to the longitudinal direction of the linear irradiation light and obtain one average spectrum. At the same time, the control device is configured to perform the cycle of the CCD detector while the stage is moving to obtain one average spectrum of the moving region of the linear irradiation region in one light detection cycle.

Microspectroscope

An initial position aligning unit performs initial positional alignment of a video and simulation data, and a position aligning unit performs positional alignment of the video and the simulation data. A first movement detecting unit detects movements of reference points which are set within a first image of the video, and a second movement detecting unit detects movement of a camera. A degree of reliability calculating unit compares the first and second movements to calculate a degree of reliability with respect to the movements of each of the reference points.

Method, apparatus, and recording medium for evaluating reference points, and method, apparatus, and recording medium for positional alignment

For assigning a binary label representing belonging to a target region or not to each pixel in an image: a predicted shape of the target region is set; a pixel group including N pixels is selected, where N is a natural number of 4 or more, which have a positional relationship representing the predicted shape; and an energy function is set, which includes an N-th order term in which a variable is a label of each pixel of the pixel group, so that a value of the N-th order term is at a minimum value when a combination of the labels assigned to the pixels of the pixel group is a pattern matching the predicted shape, and increases in stages along with an increase in a number of pixels to which a label different from the pattern is assigned. The labeling is performed by minimizing the energy function.

Image processing apparatus, and operation method and program therefor

A 9-azabicyclo[3.3.1]nonan-3-one derivative is reacted with a hydrogen in the presence of a catalyst composed of a ruthenium complex to obtain, at a low cost, an endo-9-azabicyclo[3.3.1]nonan-3-ol derivative useful as a production intermediate for agrochemical agents or medicines.

Method for producing endo-9-azabicyclo[3.3.1]nonan-3-ol derivative

When a virtual-endoscopic-image is generated from a three-dimensional-image representing a tubular-organ, a predetermined range is set in the vicinity of a viewpoint set in advance in the three-dimensional-image, and each of a lumen-region and a wall-region of the tubular-organ in the set range is identified. A voxel-value or a voxel-value-interval constituting a boundary between a range of voxel values in the identified lumen-region and a range of voxel values in the identified wall-region is obtained based on information about voxel-values in the identified lumen-region and information about voxel-values in the identified wall-region, and an opacity-curve representing a relationship between voxel values and opacity is set in such a manner that the opacity changes from a value representing a transparent-state to a value representing an opaque-state at the voxel-value or in the voxel-value-interval. The virtual-endoscopic-image is generated from the three-dimensional-image by volume rendering using the set viewpoint and the set opacity-curve.

Image processing apparatus, method and program utilizing an opacity curve for endoscopic images

A three-dimensional medical image obtainment unit that obtains a three-dimensional medical image of a chest, a bronchial structure extraction unit that extracts a bronchial structure from the three-dimensional medical image, a divided lung region obtainment unit that divides, based on the divergence of the bronchial structure, the bronchial structure into plural bronchial structures, and obtains plural divided lung regions based on the plural divided bronchial structures, a distance image generation unit that generates, based on the plural divided lung regions, a distance image based on a distance between each voxel in an entire region excluding at least one of the plural divided lung regions and each of the plural divided lung regions, and a border non-existing region extraction unit that extracts, based on the distance image generated by the distance image generation unit, a border non-existing region, which does not include any borders of the divided lung regions, are provided.

Region extraction apparatus, method and program

A process is provided for efficiently producing an optically active 3-quinuclidinol derivative of high optical purity using a readily available ruthenium compound as an asymmetric reduction catalyst. This process is a process for producing an optically active 3-quinuclidinol derivative represented by the following formula (III) comprising asymmetrically hydrogenating a 3-quinuclidinone derivative represented by the following formula (I) in the presence of a ruthenium compound (II) represented by formula (II): Ru(X)(Y)(Px)[RRC*(NRR)-A-RRC*(NRR)] (in the formulas, R represents a hydrogen atom or C7 to C18 aralkyl group and the like, X and Y represent hydrogen atoms or halogen atoms and the like, Px represents a phosphine ligand, n represents 1 or 2, R1 to R8 represent hydrogen atoms or C1 to C20 alkyl groups and the like, * represents an optically active carbon atom and A represents an ethylene group and the like). 

Production process of optically active 3-quinuclidinol derivative

A continuous-region-extraction unit extracts a continuous-region having a voxel value corresponding to an air-region in bronchi from a three-dimensional-medical-image. A tree-structure-construction unit constructs a tree-structure corresponding to the continuous-region. A linear-structure-extraction unit extracts plural linear-structures representing fragments of small-bronchi by analyzing a local density structure in a neighborhood of each point in the three-dimensional-medical-image. A tree-structure-reconstruction unit reconstructs a graph-structure representing the whole bronchi by connecting a node constituting the graph-structure of large-bronchi and a node representing the linear-structures of small-bronchi. At this time, different cost functions are used for a segment connecting the node of the large-bronchi and the node representing the linear-structures of the small-bronchi and a segment connecting the nodes representing the linear-structures to each other. The cost function in the former segment is defined in such a manner that the segment is more likely to be connected as a change in voxel values is smaller.

Medical image processing apparatus, method and program

It is to provide a novel optically active dibenzazepine derivative having a high utility value as an asymmetric phase-transfer catalyst. It is an optically active 6,7-dihydro-5H-dibenzo[c,e]azepine derivative represented by the following formula (1'), (wherein R represents a divalent organic group for cross-linking the 1position and the 11position; Rand Rare the same or different, and represent a hydrogen atom, halogen atom, or organic group, or Rand Rtogether represent a divalent organic group; Rand Rare the same or different and represent a monovalent organic group, or Rand Rtogether form an organic group that forms a cyclic structure comprising an onium nitrogen atom; Ar represents a monovalent organic group; * represents optical activity, i.e., that one axially asymmetric isomer is present in excess of the other axially asymmetric isomer with respect to a bond axis that constitutes the biphenyl structure of the compound; and Xrepresents a counter anion). 

Optically active dibenzazepine derivatives

Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG.; a pharmaceutically acceptable salt thereof; a hydrate of the derivative or the salt; and a solvate of the derivative or the salt. (In the formula, Rand Rmay be the same or different and each represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylsulfanyl group, an alkylsulfinyl group, an alkylsulfonyl group, a lower alkyl-substituted carbamoyl group, a saturated nitrogen-containing heterocyclic N-carbonyl group, a halogen atom, a cyano group or a hydrogen atom; Rrepresents a lower alkyl group, a haloalkyl group, a halogen atom, a hydroxy group or a hydrogen atom; and X represents a sulfur atom, an &#x2014;S(&#x2550;O)&#x2014; group or an &#x2014;S(&#x2550;O)&#x2014; group.)

Phenol derivative

Disclosed herein are optically active biphenol derivatives represented by the following formulas (1) and (2), a method for optically resolving a biphenol derivative represented by formula (2'), a production method of an optically active biphenol derivative (1) comprising a step for reacting a Br&#xf8;nsted acid with a biphenol derivative (2), and a production method of an optically active biphenol derivative (3) comprising a step for reacting a Lewis acid with an optically active biphenol derivative (1) or an optically active biphenol derivative (2). 

Optically active 2,2'-biphenol derivative and production method of same

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Tokyo, Japan

Tsutomu Inoue