Canon Kabushiki Kaisha

Tsutomu Honma

Tetsuya Yano

Takeshi Imamura

Takashi Kenmoku

Shinya Kozaki

Etsuko Sugawa

Tsuyoshi Nomoto

Sakae Suda

Tatsuki Fukui

Shin Kobayashi

Tomohiro Suzuki

Chieko Mihara

Toyoko Kobayashi

Ako Kusakari

Fumio Yamauchi

Satoshi Ogawa

Kengo Kanazaki

Shigeki Yoshida

Sachiko Inoue

Akiko Tsuchitani

The present invention provides a composite particle having a high molar absorption coefficient for detection with higher detection sensitivity in photoacoustic imaging. In the present invention, a composite particle having a particle, a single-chain antibody which includes an antigen recognition region and a region other than the antigen recognition region and which is conjugated with the particle, and an organic dye conjugated with the single-chain antibody, in which the region other than the antigen recognition region of the single-chain antibody has thiol group, and a functional group of the particle is bound to the thiol group, is provided.

Composite particle, contrast agent for photoacoustic imaging, and method for producing the composite particle

To provide a toner for developing electrostatic images which is not easily cause the phenomenon of toner-spent, constituent materials are so selected that a charge control resin has hardness which is the same as the hardness of a binder resin or the charge control resin is harder than the binder resin, as measured with a scanning probe microscope in a viscoelasticity evaluation mode in respect to the binder resin and the charge control resin which are present in the particle interiors or particle surfaces of the toner.

Toner for developing electrostatic images

The invention provides a novel polyester adapted for use in a charge control agent for a toner for an electrophotographic process, having a charge stability, a high charge amount, an improved dispersibility and a biodegradability, and a producing method and an application technology therefore. According to the invention, there is provided polyhydroxyalkanoate comprising at least one unit represented by the following chemical formula in a molecule:&#x2014;(O&#x2014;CH(&#x2014;(CH)&#x2014;CH-p-CH&#x2014;CONH-ASOR)CHCO)&#x2014;(wherein Rrepresents OH, a halogen atom, ONa, OK or OR; Aand Reach represents a substituted or unsubstituted aliphatic hydrocarbon structure, a substituted or unsubstituted aromatic cyclic structure or a substituted or unsubstituted heterocyclic structure; m represents an integer selected from a range of 0 to 7; and R, A, Rand m have the aforementioned meanings independently for each unit when plural units are present), a charge control agent containing such polyhydroxyalkanoate, a toner utilizing such charge control agent, and an image forming method and an image forming apparatus utilizing such toner.

Polyhydroxyalkanoate having amide, sulfonic acid or sulfonate ester group, charge control agent and toner

A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the steps of immobilizing a polyhydroxyalkanoate synthase on the base material surface, synthesizing, on the base material surface, polyhydroxyalkanoate using a 3-hydroxyacyl coenzyme A to become the substrate of the synthase and the synthase and coating at least a part of the base material surface with the synthesized polyhydroxyalkanoate, wherein the synthase contains an amino acid sequence capable of binding to the base material. A polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with a polyhydroxyalkanoate, comprises the base material, a polyhydroxyalkanoate synthase immobilized on the base material surface, and the polyhydroxyalkanoate with which at least a part of the base material surface is coated, wherein the synthase contains an amino acid sequence capable of binding to the base material.

Polyhydroxyalkanoate-containing structure and manufacturing method thereof

The invention provides a particulate construct comprising a polyhydroxyalkanoate to serve as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation.

Particulate construct comprising polyhydroxyalkanoate and method for producing it

A structure containing polyhydroxyalkanoate and a magnetic substance includes an external phase part containing polyhydroxyalkanoate and an internal phase part contained in the external phase part, at least one of the external phase part and the internal phase part containing a magnetic substance. Accordingly, provided is a microcapsule, which can be suitably used for formation of an active ingredient of a sustained release pharmaceutical preparation or an ultrasonic contrast agent.

Polyhydroxyalkanoate-containing magnetic structure, and manufacturing method and use thereof

A novel polyhydroxyalkanoate having a monomer unit represented by the formula (1), the unit having a carboxyl group substituting a ring structure at the end of side chain, obtainable by oxydizing vinyl or methyl group substituting a ring structure at the end of the side chain. The polyhydroxyalkanoate has high thermal stability, charge stablity, a high charge amount, improved dispersibility and biodegradability together, and therefore, suitable for resin moldings, and binders and charge controlling agents for toners used in the electrophotographic process. 

Polyhydroxyalkanoate, process for preparing the same, and resin composition containing the polyhydroxyalkanoate

A polyhydroxyalkanoate copolymer comprises one kind of unit of&#x2014;[OCH((CH)&#x2014;SOCHR)CHCO]&#x2014; (n=1-7)&#x2003;&#x2003;(1)(wherein R is any one of H, halogen, CN, NO, COOR', SOR&#x2033; (R&#x2032; is any one of H, Na, K, CHand CH; R&#x2033; is any one of OH, ONa, OK, halogen, OCHand OCH), CH, CH, CH, (CH)&#x2014;CH and (CH)&#x2014;C) and&#x2014;[OCH((CH)&#x2014;SOCHR)CHCO]&#x2014; (n=1-7)&#x2003;&#x2003;(2)(wherein R is any one of H, halogen, CN, NO, COO R&#x2032;, SOR&#x2033; (R&#x2032; is any one of H, Na, K, CHand CH; R&#x2033; is any one of OH, ONa, OK, halogen, OCHand OCH), CH, CH, CH, (CH)&#x2014;CH and (CH)&#x2014;C) and at least one unit of chemical formulae (3) to (6):&#x2014;[OCH((CH)&#x2014;Rz)CHCO]&#x2014; (n=1-8) &#x2003;&#x2003;(3)(wherein Rz comprises a residue having either a phenyl structure or a thienyl structure),&#x2014;[OCH((CH)&#x2014;CHRa)CHCO]&#x2014; (n=1-8)&#x2003;&#x2003;(4)(wherein Ris any one of H, CN, NO, halogen, CH, CH, CH, CF, CFand CF)&#x2014;[OCH((CH)&#x2014;CH&#x2550;CH)CHCO]&#x2014; (n=1-8), and&#x2003;&#x2003;(5)&#x2014;[OCH((CH)&#x2014;COORb)CHCO]&#x2014; (n=1-8)&#x2003;&#x2003;(6)(wherein Ris any one of H, Na and K).

Polyhydroxyalkanoate copolymer, resin composition, molded product, toner, image forming method and image forming apparatus

The invention provides a PHA copolymer including at least a 3-hydroxy-&#x3c9;-carboxyalkanoic acid represented by a formula (19) or (32) and simultaneously at least a unit represented by a formula (2) or a formula (3) in a molecule, a precursor PHA copolymer having a corresponding vinyl group or a corresponding alkoxycarbonyl group, a biosynthesis method thereof by microorganisms, and a method of producing a desired PHA copolymer from the precursor PHA copolymer: (wherein k, m, n are integers; Rrepresents H, Na, K, R27? represents (A); Rrepresents a substituent on a cyclohexyl group and represents H, CN, NO, a halogen atom, CH, CH, CH, CF, CF, or CF; R includes a residue including a phenyl structure or a thienyl structure; these being independent for each unit). 

Polyhydroxy alkanoate copolymer including within molecule unit having vinyl group or carboxyl group in side chain, and producing method therefor

A polyhydroxyalkanoate is disclosed which has in the molecule a unit represented by Chemical Formula (1). wherein R is arbitrarily selected from a hydrogen atom, a halogen atom, CN, NO, COOR', SOR&#x2033;, CH, CH, CH, C(CH)H and C(CH); where R&#x2032; is H, Na, K, CHor CH, and R&#x2033; is OH, ONa, OK, a halogen atom, OCHor OCH; and x is an integer arbitrarily selected from 1 to 8; with the proviso that a polyhydroxyalkanoate is excluded which has a hydrogen atom as R and x in all the units is 2 or 4. Also disclosed is a process for producing the polyhydroxyalkanoate by the use of a microorganism having the ability to produce the polyhydroxyalkanoate and accumulate it in the bacterial body.

Polyhydroxyalkanoate containing unit with phenylsulfanyl structure in the side chain, process for its production, charge control agent, toner binder and toner which contain novel polyhydroxyalkanoate, and image forming method and image-forming apparatus which make use of the toner

An assay method for determining presence of a target antibody or antigen in a specimen qualitatively or quantitatively by mixing the specimen with an antigen or antibody immunologically reactive with the target antibody or antigen, and assaying the level of the immunological agglutination reaction, wherein the reactive antigen or antibody is effectively immobilized on the carrier via an amino acid sequence capable of binding to the carrier.

Immunoassay, reagent for immunoassay, and production method of the same

A polyhydroxyalkanoate containing in a molecule at least one unit represented by the chemical formula (1). The polyhydroxyalkanoate is a biodegradable plastic with enhanced melt-processability and exhibits excellent charging stability, high chargeability, and enhanced dispersibility when used as a charge control agent of a toner in an electrophotographic process. 

Polyhydroxyalkanoate containing amide group, sulfonic group, and sulfonate ester group, method for producing the same, and charge control agent, toner, image forming method, and image forming apparatus

A process for forming a fine pattern comprised of a polyhydroxyalkanoate on a substrate is provided. The process comprises steps of applying a polyhydroxyalkanoate-synthesizing enzyme and a 3-hydroxyacyl CoA to coexist in an intended pattern on a substrate, and polymerizing the 3-hydroxyalkanoate by action of the enzyme to form the polyhydroxyalkanoate in a pattern on the substrate. In particular, the fine pattern can be formed by an inkjet system.

Process for formation of pattern of polyhydroxyalkanoate

A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a bio-substance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier.

Magnetic substance-biosubstance complex structure, peptide fragment capable of linking to magnetic substance and gene therefor, and process for producing the complex structure

Disclosed are a polyhydroxyalkanoate, containing in a polymer molecule thereof a monomer unit represented by the following general formula (1): (wherein R1 represents a substituent to a cyclohexyl group, where R1 is a H atom, a CN group, a NOgroup, a halogen atom, a CHgroup, a CHgroup, a CHgroup, a CFgroup, a CFgroup, or a CFgroup; and if there are two or more monomer units, R1 may be different from every monomer unit), and a binder resin using the polyhydroxyalkanoate. The binder resin is biodegradable, so that the binder resin is more responsible for the conservation of natural environment or the like. Also, the binder resin facilitates deinking in the deinking process using an alkali, so that the binder resin accelerates recycling of used copying paper. Furthermore, the binder resin satisfies the desired characteristics of a toner for developing an electrostatic charge image.

Polyhydroxyalkanoate containing unit having cyclohexyl structure at side chain, production process therefor, and binder resin containing polyhydroxyalkanoate

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Kanagawa, Japan

Tsutomu Honma