Juridical Foundation the Chemo-sero-therapeutic Research Institute

The Chemo-sero-therapeutic Research Institute

Tsutomu Hamuro

Hiroshi Kaetsu

Tatsuya Araki

Shintaro Kamei

Sumiyo Takemoto

Yo Nakahara

Seiji Miyamoto

Yuichi Kamikubo

Shinichi Miyagawa

Mika Okuda

Hideki Saga

A fibrinogen preparation is provided which has an improved solubility, may be prepared within a short time and may be used rapidly in clinical set-up. A solid fibrinogen preparation comprising as a main ingredient fibrinogen and further containing the following components: albumin; a nonionic surfactant; a basic amino acid or a salt thereof; and at least two amino acids or a salt thereof selected from an acidic amino acid or a salt thereof and a neutral amino acid or a salt thereof. The solid fibrinogen composition of the present invention may be held on a medical material to form a supporting material holding fibrinogen. Besides, the supporting material holding fibrinogen may be combined with a component comprising as a main ingredient thrombin to provide a fibrin adhesive.

Solid fibrinogen preparation

In a process for preparing Tissue Factor Pathway Inhibitor (TFPI) by the genetically engineered technique by the use of a transformed animal cell wherein a DNA encoding human TFPI is introduced, the improvement which comprises culturing said transformed animal cell in a culture medium supplemented with a sulfated polysaccharide to protect an intact TFPI produced by said transformed animal cell from cleavage by proteases present in the culture medium.

Process for preparing tissue factor pathway inhibitor

Neovascularization inhibitor containing tissue factor pathway inhibitor

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Kumamoto, Japan

Tsutomu Hamuro