Otsuka Pharmaceutical Company, Limited

Tsutomu Fujiwara

Takeshi Watanabe

Masato Horie

Sadahito Shin, Deceased

Takashi Okamoto

Yoshikazu Shimada

Mikio Suzuki

Kouichi Ozaki

Hisanobu Hirano

Hiroyuki Kyushiki

Yasuchika Yamamoto

Atsunori Ueyama

Shiro Okuno

Masashi Niimi

Satoshi Takeda

The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

Nel-related type 1 polypeptide

Human skeletal muscle-specific ubiquitin-conjugating enzyme

Nel-related protein type 1 antibody

Human gene

An isolated and purified human skeletal muscle-specific ubiquitin-conjugating enzyme comprising the amino acid sequence shown in SEQ ID NO: 22 is disclosed. The use of the genes make it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

The present invention is drawn to a gene comprising a polynucleotide encoding a polypeptide composed of an amino acid sequence represented by SEQ ID NO: 1; a gene expression product produced through expression of the gene; a recombinant expression vector including the gene; a host cell (transformant) harboring the recombinant expression vector; a protein composed of an amino acid having an amino acid sequence represented by SEQ ID NO: 1; a therapeutic or preventive composition for hypoglycemia containing as an active ingredient the above-mentioned gene or protein; and an antibody capable of binding to the protein. Through use of the gene or an expression product thereof of the present invention, it is possible to elucidate the pathology of diabetes and develop drugs for treatment and prevention of diabetes via a new action mechanism.

Enzyme gene and its expression product

An isolated and purified human skeletal muscle-specific ubiquitin-conjugating enzyme comprising the amino acid sequence shown in SEQ ID NO:22 is disclosed. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

An isolated nucleic acid molecule encoding human skeletal muscle-specific ubiquitin-conjugating enzyme and comprising a nucleotide sequence coding for the amino acid sequence shown in SEQ ID NO:22 is disclosed. The isolation of this molecule makes it possible to detect its expression in various tissues, analyze its structure and function, and produce the human proteins encoded by this molecule by the technology of genetic engineering. In this way, it is possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the molecule, for example hereditary diseases and cancer, and diagnose and treat such diseases.

Method for detecting expression of human skeletal muscle-specific unbiquitin-conjugated enzyme

Human nucleosome assembly protein gene

Isolated nucleic acid molecule encoding human skeletal muscle-specific

FK506-binding protein gene

The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO: 1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

Human NPIK gene

Human GDP dissociation stimulating protein gene

The present invention provides a human GRP17 gene which comprises a nucleotide sequence coding for the amino acid sequence of SEQ ID NO:1. The gene can be used in the expression and detection of the GRP17 protein and in the diagnosis of various diseases in which the protein is involved, pathological studies of such diseases, and screening out and evaluation of drugs for the treatment and prevention of such diseases.

GRP17 gene

Growing community of inventors

Naruto, Japan

Tsutomu Fujiwara