Shionogi Company Limited

Nippon Pneumatic Manufacturing Co., Ltd.

Tsutomu Aoki

Wataru Nagata

Yasuhiro Nishitani

Toshiro Konoike

Teruji Tsuji

Shoichiro Uyeo

Fukuo Wakano

Mitsuru Yoshioka

Tadatoshi Kubota

Hiroshi Itazaki

Hikaru Itani

Masaaki Hiraoka

Hiromi Takahashi

Yasuo Umemura

Masahiro Ida

Hitomi Nakai

Hirohumi Tsuyuguchi

Osamu Date

Reiji Takada

Kozo Najima

Kyo Okada

A process for producing a compound of the formula (II): wherein Halrepresents halogen and Rand Reach independently represents halogen, alkyl, alkoxy, nitro or cyano, which comprises allowing a halogenating agent to react with a compound of the formula (I): wherein Alk represents branched alkyl and Rand Rare as defined above.

Process for producing arylsulfenyl halide

A vibrating cutting tool capable of making uniform micro-vibrations at the cutter edge generated during machining. The vibrations at the cutter edge are transmitted to balls biassed by springs, compressing the springs. The vibrations are transmitted from the balls through the output shaft back to the cutter edge. While the cutting force is small, the amplitude of vibration of balls is relatively large. When it increases, the holder acts on the balls more than the spring does so that vibration is suppressed. As a result, the amplitude of vibration becomes uniform.

Vibrating cutting tool

A vibrating cutting tool having an input shaft driven by a live spindle of a machine tool and an output shaft having a cutter mounting portion. The input shaft and the output shaft are coupled together through a coupling mechanism so as to be at least circumferentially movable relative to each other. Recesses are formed in one of the input shaft and the output shaft and holes are formed in the other at locations opposite to the recesses. Moving elements are mounted between the recesses and the holes with a predetermined gap defined between the moving elements and the recesses or the peripheral surfaces of the holes. The gaps serve to restrict a circumferential movement of the moving elements. Springs are provided to urge the moving elements against the recesses. The movement of the moving elements is restricted by stoppers. An adjusting ring may be provided to adjust the biasing force of the springs.

An antibacterial cephalosporin hydroxamic acid derivative represented by the following formula (I), processes for its preparation, compositions containing the same as an active ingredient, and a method for killing bacteria by contacting with said compound. ##STR1## (wherein, R is acyl; R.sup.1 is hydrogen or methoxy; R.sup.2 is alkylene; R.sup.3 is hydrogen, aliphatic group or a hydroxy-protecting group; R.sup.4 is hydrogen or amino-protecting group; R.sup.5 is hydrogen, light metal atom or carboxy-protecting group; and X is oxygen, sulfur, or sulfinyl).

1-oxadethia cephalosporin hydroxamic acid derivatives

A tool abnormality detector for use with a machine tool for detecting any abnormality of a tool mounted on the tool mounting shaft. When the tool mounting shaft is in a correct position with respect to the tubular body secured to the spindle, the air pressure is kept constant. When an abnormal resistance is applied to the tool mounting shaft, the latter will lag in rotation with respect to the tubular body, so that the exhaust air passage will be blocked. A pressure sensor detects an abnormal increase in the air supply line, giving a signal for stopping the spindle of the machine tool. This prevents the tool from damage.

Tool abnormality detector

Cephalosporin hydroxamic acids

A novel chemical, fluorochlorocyclopropane (I) of the following formula: ##STR1## is prepared by the addition of fluorochlorocarbene to the corresponding olefin (II) of the following formula:

Fluorocyclopropanes

5-Mercapto-1H-tetrazole-1-alkanohydroxamic acid, its salts and its esters having the following formula: ##STR1## wherein A is an alkylene group;

Mercaptotetrazolylalkanohydroxamic acids, salts and ester thereof

A compound of the formula: ##STR1## wherein u represents hydrogen, carboxamido, N-hydroxycarboxamido, carboxy, azido, an aryl, an acylamino, a protected carboxy or an N-alkoxycarboxamido, or, together with v, can represent --S-- or --CH.sub.2 S--; v represents hydrogen, halogen, cyano or an alkylthio, or, together with u, can represent --S-- or --CH.sub.2 S--, or, together with w, can represent --(CH.sub.2).sub.3 CO--; w represents hydrogen, carboamoyl, cyano, carboxy, an N-alkylcarbamoyl, an alkyl, an aryl, a protected carboxy or a heterocycle, or, together with v, can represents --(CH.sub.2).sub.3 CO--; x represents halogen, trifluoromethyl, an alkylthio or an arylthio; y represents hydrogen, a light metal or a carboxylic acid protecting group; and z represents an acyloxy or a heterocycle-thio, each of the above radicals represented by the symbols u, v, w, x, y and z being optionally substituted by halogen or a carbon-, nitrogen-, oxygen- or sulfur-containing functional group, a process for preparing the compound, a pharmaceutical composition containing the compound, and a therapeutical use of the compound. A compound of the formula: ##STR2## wherein u, v, w and x are as defined above, useful as a starting compound for preparing the compound (I) is also provided.

Vinylthioacetamido oxacephalosporin derivatives

A process for preparing 3.beta.-amino-4.beta.-substituted-2-azetidinones, which comprises condensing a 3.alpha.-amino-4.beta.-substituted-2-azetidinone with a trihalogenoacetaldehyde or the reactive derivative thereof to give a 3.alpha.-(2,2,2-trihalogenoethylidene)amino-4.beta.-substituted-2-azetidin ones, treating the latter with a base to give a 3-(2,2-dihalogenovinyl)imino-4.beta.-substituted-2-azetidinone, reducing the latter with a metal hydride to give a 3.beta.-(2-halogenovinyl)amino-4.beta.-substituted-2-azetidinone, and hydrolyzing the latter to give the objective compound.

Inversion of the 3.alpha.-amino group attached to the .beta.-lactam ring

Inversion of the 3 .alpha.-amino group attached to the .beta.-lactam ring

Compounds of the formula: ##STR1## (where COB is carboxy or protected carboxy and X is hydrogen or nucleophilic group) preparable by oxidation of the corresponding N-nitrosopenicillin derivatives are useful as starting materials for synthesizing known and useful cephalosporins.

Penicillin oxides

Antibacterial compounds of the formula ##STR1## (where COB is carboxy or protected carboxy;

2-Halomethyl-2-nucleophilic substituted methyl penicillins

A novel process for producing o-hydroxybenzyl alcohols useful as raw materials or intermediates in chemical or pharmaceutical industries, which comprises reacting phenols or naphthols with aromatic boronic acids and aldehydes in the presence of organic carboxylic acids, followed by degradation of the cyclic ester intermediates.

Growing community of inventors

Osaka, Japan

Tsutomu Aoki