Kyowa Hakko Kogyo Co., Ltd.

Tsutomu Agatsuma

Yutaka Saitoh

Yoshinori Yamashita

Shiro Akinaga

Katsuhiko Ando

Tamio Mizukami

Akira Asai

Keiko Ochiai

Katsushige Gomi

Yuzuru Matsuda

Takeo Tanaka

Hidemasa Kondo

Fumito Koizumi

Takeshi Takahashi

Yutaka Kanda

Tsutomu Akama

Hirofumi Nakano

Chikara Murakata

Eiji Tsukuda

Yasushi Sakai

Isami Takahashi

Nobuyoshi Amishiro

Shun-ichi Ikeda

Ryuichiro Nakai

Youichi Uosaki

Shinji Nara

Hideki Kawasaki

Kozo Ouchi

Yoji Ino

Harumi Ogawa

Kazuhito Akasaka

Mayumi Miyata

Tetsuo Yoshida

Katsunori Kita

Noboru Fujii

Yasushi Nishiie

Kozue Muramatsu

Naoki Morishima

Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I):{wherein Rand Rare the same or different and represent a hydrogen atom, a lower alkyl group or, etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a cyano group, an amino group, COR(wherein Rrepresents a substituted lower alkyl group etc.), a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, etc}, or pharmaceutically acceptable salts thereof.

Estra-1,3,5(10)-triene derivatives

UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I):wherein Rrepresents hydrogen, lower alkyl, etc.; Rrepresents hydrogen, or is combined with Rto represent a bond, etc., or is combined with Rto represent &#x2014;O(C&#x2550;O)&#x2014;, etc.; Rrepresents hydrogen, etc., or is combined with Rto represent a bond, etc.; Rrepresents hydrogen, etc., or is combined with Rto represent &#x2014;(C&#x2550;O)O&#x2014;, etc.; Rrepresents hydrogen or is combined with Rto represent a bond; Rrepresents hydrogen, etc., or is combined with Rto represent a bond; Rrepresents hydrogen or is combined with Rto represent &#x2550;O; Rrepresents hydroxy or is combined with Rto represent &#x2550;O;represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.

UCS1025 derivatives

The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; (1) when X represents halogen, Y represents an oxygen atom or R.sup.4 --O--N (wherein R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl); and R.sup.3 represents hydrogen, alkanoyl, alkenoyl or the like; and (2) when X and R.sup.3 are combined with each other to represent a single bond; Y represents R.sup.4B --O--N (wherein R.sup.4B has the same meaning as R.sup.4). The radicicol derivatives of the present invention demonstrate tyrosine kinase inhibition activity and pharmacological activities such as antitumor, antimicrobial or immunosuppression effects.

Radicicol derivatives

Physiologically active substance EI-2128-1

Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl.

Interleukin-1 production inhibiting compound

UCS1025 compounds represented by the following formula (I): ##STR1## wherein R represents hydrogen or hydroxyl group, or tautomers or pharmacologically acceptable salts thereof.

UCS1025 compounds

A GE3 compound of the formula (I) having antibacterial and antitumor properties: ##STR1##

GE3 compound

Saintopin derivatives

Growing community of inventors

Machida, Japan

Tsutomu Agatsuma