Syntex (u.s.a.) Inc.

Tsung-Tee Li

Joseph M Muchowski

Jurg R Pfister

Robert J Greenhouse

Colin C Beard

Gary F Cooper

Douglas L Wren

Albert R Van Horn

Jack Ackrell

This invention relates to a process for making a compound of formula I ##STR1## in the form of a stereoisomer or mixture thereof, wherein R is hydrogen, lower alkyl; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, and the wavy lines represent the .alpha. or .beta. configuration with the proviso that when one wavy line is .alpha. the other is .beta., or a pharmaceutically acceptable, non-toxic salt of the compound wherein R is hydrogen; novel intermediates useful for preparing these compounds; processes for making the intermediates; and a stereoisomer of the compound of formula I wherein R is methyl and X is hydrogen and a process for making same.

Processes and intermediates for making 16-phenoxy- and 16-substituted

A compound of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof are potent antihypertensive agents and are therefore useful as cardiovascular system regulators. These compounds are also useful as bronchodilators.

+2-[(3,4-Methylenedioxy)phenethyl]-5-[(3-carboxamido-4-hy

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Los Altos, CA, United States of America

Tsung-Tee Li