National Taiwan University

Innopharmax, Inc.

Tsh Biopharm Corporation Ltd.

Tsung-Hsin Lin

Yao-Hong Liu

Wei-Hua Hao

Ta-Chien Lu

A controlled release carvedilol formulation for less frequent, preferably once daily administration is described. The controlled release formulation comprises a therapeutically effective amount of carvedilol or a pharmaceutically acceptable salt thereof, a matrix forming polymer, a solubility enhancer and a pharmaceutically acceptable carrier. In one embodiment, a controlled release formulation having a therapeutically effective amount of carvedilol is contained in two or more subunits having different release profiles. The controlled release formulation is usable in the treatment and/or prophylaxis of one or more conditions such as cardiovascular disorders.

Controlled release carvedilol formulation

A pulse width (PW) digitizer comprises a current pump, a capacitor, a quantizer, a feedback controller, and a digital filter. The current pump provides a current signal in response to a PW signal. The capacitor obtains a voltage signal in response to the current signal. The quantizer obtains a digital signal in response to the voltage signal. The feedback controller determines a feedback PW signal in response to the digital signal. The feedback PW signal is fed back to the current pump for controlling the current signal converging to a specific value and controlling the digital signal switching between a first code and a second code. The digital filter counts times that the digital signal indicating the first code/the second code and accordingly obtains the PW of the PW signal.

Pulse width digitizing method and pulse width digitizer using thereof

A frequency shift keying modulator having sigma-delta modulated phase rotator is disclosed, which includes a phase-locked loop for generating a voltage-controlled signal; a multi-phase generator for receiving the voltage-controlled signal and generating N phase-shift signals having same frequency according to the voltage-controlled signal, the N phase-shift signals having a same phase shift between the phase-shift signals adjacent to each other; a sigma-delta modulator for receiving transmission data and randomly outputting a modulation bit at a modulation clock according to the transmission data; and a phase rotator for receiving the N phase-shift signals and selectively outputting one of the N phase-shift signals and a frequency-divided signal according to the modulation bit, wherein the frequency of the frequency-divided signal is of the frequency of any one of the N phase-shift signals.

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Taipei, Taiwan

Tsung-Hsin Lin