Ono Pharmaceutical Co., Ltd.

Ono Pharmaceuticals Co., Ltd.

Tsuneyuki Sugiura

Kanji Takahashi

Tohru Miyazaki

Katsuhito Sakaki

Hiroyukii Ohno

Hidekazu Kanazawa

Aminobutylic acid derivatives of the formula (I):wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds of the formula (I) are useful for prevention and/or treatment of diseases, for example, rheumatoid diseases, arthrosteitis, osteoarthritis, unusual bone resorption, osteoporosis, periodontitis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, cornea ulcer, metastasis, invasion or growth of tumor cells, autoimmune disease, disease caused by vascular emigration or infiltration of leukocytes, arterialization, multiple sclerosis, arota aneurysm, endometriosis, restenosis after PTCA, unstable angina, acute myocardial infarction, transient ischemic attack.

Aminobutyric acid derivatives and pharmaceutical composition containing the same as active ingredient

4-aminobutanoic acid derivatives and drugs containing these derivatives as the active ingredient

Aminobutyric acid derivatives

Method of treating disease with sulfonylamino acid derivatives

Pharmaceutical composition containing aryl (sulfide, sulfoxide, sulfone) derivatives of the formula (1) and the salts thereof as active ingredient (wherein R,is H, alkyl; R,is COOR,, CONHOR,; E is &mdash;CONR,&mdash;, &mdash;NR,CO&mdash;, &mdash;OCO&mdash;,&mdash;COO&mdash;, &mdash;CH,&mdash;O&mdash;, &mdash;(CH,),&mdash;, vinylene, ethynylene; J is bond, alkylene; A is H, alkyl, Ar, alkyl-OH ; R,, R,is H, alkyl, COOR,, hydroxy, &mdash;NR,R,,

Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient

Sulfonylamino acid derivatives

Hydroxamic acid derivatives

Growing community of inventors

Mishima-gun, Japan

Tsuneyuki Sugiura