Otsuka Pharmaceutical Company, Limited

Tsuneyuki Noda

Atsushi Ueda

Masamichi Toba

Megumi Kumemura

Seiichi Shimizu

Takao Saito

Noriyuki Kouda

Takuma Imada

Hiroshi Okamatsu

Kyosuke Masaki

Takeshi Ikenaga

Tatsuya Doi

Yoshito Tajiri

The present disclosure relates to astrain having polyamine production promoting activity in an organism, as well as its application and relevant technologies. The present disclosure also relates to the use of thestrain to promote polyamine production in humans and animals, which may be used, for instance, to reduce hepatic neutral fat. The present disclosure also relates to the use of thestrain as an agent to prevent or treat a disease, including fatty liver, non-alcoholic steatohepatitis, and liver cirrhosis.

strain

The invention provides an immunopotentiating composition and to a composition accelerating the production of interferon-&ggr;, both comprising lactosuclose as an active ingredient. In particular, the invention provides such compositions in the form of a foodstuff. Oral administration or ingestion of the compositions enhances biophylaxis mechanism (immunological function) in the digestive tract, thus achieving significant treating and preventing effects on intestinal infections and like diseases.

Immunopotentiating compositions

A method of inhibiting liver fat accumulation which comprises administering a conjugated linoleic acid homolog to a mammal or making the mammal ingest it; and a liver fat accumulation inhibitory composition characterized by containing an effective amount of a conjugated linoleic acid homolog together with a support for medicinal preparations or foods. The administration or ingestion of CLA inhibits the total lipid content and the triglyceride content in the liver from increasing, and hence can effectively prevent diseases attributable to fatty liver, such as chronic hepatitis and hepatic cirrhosis.

Liver fat accumulation inhibitory composition, food additive for liver fat accumulation, inhibition, and method of inhibiting liver fat accumulation

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Otsu, Japan

Tsuneyuki Noda