Other

Tsuneyasu Kaisho

Toshio Hirano

A gene encoding a novel membrane protein polypeptide having pre-B cell growth-supporting ability and a membrane protein polypeptide consisting of 180 amino acid residues having pre-B cell growth-supporting ability. This gene encodes the membrane protein having pre-B cell growth-supporting ability. A method for producing a membrane protein having pre-B cell growth-supporting ability by transforming a host cell with a vector containing a gene encoding it and culturing the resulting transformants. A monoclonal antibody recognizing this membrane protein. The homogeneous and purified novel membrane protein pelypeptide can be produced in large quantities and used to produce monoclonal antibodies useful for identifying rheumatoid arthritis (RA) and for the preparation of reagents for the clinical diagnosis thereof.

Antibody reactive with a protein having pre-B cell growth-supporting ability

The present invention provides a monoclonal antibody which binds to a polypeptide as set forth in SEQ ID NO: 1 as described herein.

Monoclonol antibody which binds to a polypeptide having pre-B cell growth supporting ability

Method of identifying cells expressing a protein having pre-B cell growth-supporting ability

The present invention provides (1) a polypeptide containing amino acids 1 to 269 of the amino acid sequence shown in SEQ ID No: 1, (2) polypeptide containing amino acids 1 to 290 of the amino acid sequence shown in SEQ ID No. 1, (3) a polypeptide containing amino acids &minus;28 to 269 of the amino acid sequence shown in SEQ ID No. 1, and (4) a polypeptide containing amino acids &minus;28 to 290 of the amino acid sequence shown in SEQ ID No. 1. The present invention also provides a fusion protein in which residues 1 to 269 of SEQ ID No. 1 are linked to a second polypeptide and a fusion protein in which residues 1 to 290 of SEQ ID No. 1 are linked to a second polypeptide.

Gene encoding a polypeptide having pre-B cell growth-supporting ability

Isolated DNAs which encode polypeptides having pre-B cell growth-supporting ability.

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Hyogo, Japan

Tsuneyasu Kaisho