Kaken Pharmaceutical Company, Ltd.

Other

Kaken Kagaku Kabushiki Kaisha

Tsuneo Saita

Keiji Sekine

Nobuo Ishiyama

Takanobu Naito

Hisato Senda

Masaaki Yokoyama

Yoshiyuki Zama

Taiji Asano

Masao Hirose

Shigeru Sanai

Makoto Yamamoto

Akira Kawarada

Setsuo Takeuchi

Yukio Inoue

Mutsuyuki Kochi

Shinichiro Esumi

Kaguya Sasaki

Shozo Kawabata

A cephalosporin compound having the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, a methoxy group, a substituted or unsubstituted vinyl group, or --CH.sub.2 --A wherein A is a hydrogen atom, an azido group, an acyloxy group, a carbamoyloxy group, a substituted or unsubstituted heterocyclic group (wherein the hetrocyclic ring is a 5- or 6-membered heterocyclic ring having from 1 to 4 oxygen, nitrogen or sulfur atoms), or a substituted or unsubstituted heterocyclic thio group (wherein the heterocyclic ring is a monocyclic or bicyclic heterocyclic ring having from 1 to 5 oxygen, nitrogen or sulfur atoms), or a pharmaceutically acceptable salt thereof.

Cephalosporin compounds, processes for their preparation and

Disclosed is a novel carcinostatic composition comprising 4,6-0-benzylidene-D-glucopyranose as the active ingredient. This active ingredient exerts a very high carcinostatic activity according to a specific carcinostatic mechanism quite different from that of conventional carcinostatic chemotherapeutic agents. The active ingredient is very low in toxicity and is highly stable and water-soluble. This composition is effective against selected malignant conditions which are carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver and malignancies induced by SV.sub.40 virus.

A composition and method of treating selected malignant conditions

A cephalosporin compound having the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, a methoxy group, a substituted or unsubstituted vinyl group, or --CH.sub.2 --A wherein A is a hydrogen atom, an azido group, an acyloxy group, a carbamoyloxy group, a subsituted or unsubstituted heterocyclic group (wherein the hetrocyclic ring is a 5- or 6-membered heterocyclic ring having from 1 to 4 oxygen, nitrogen or sulfur atoms), or a substituted or unsubstituted heterocyclic thio group (wherein the heterocyclic ring is a monocyclic or bicyclic heterocyclic ring having from 1 to 5 oxygen, nitrogen or sulfur atoms), or a pharmaceutically acceptable salt thereof.

Cephalosporin compounds, and antibacterial agents

Growing community of inventors

Tokyo, Japan

Tsuneo Saita