Lion Corporation

Tsuneo Miyahara

Katsuyuki Futakami

Yoji Yamazaki

Yasukuni Nishida

Ryoko Konishi

Toshiyuki Okada

There is provided a dental caries-preventive composition containing an antibody and a nonionic surface active agent, said antibody being obtained from an animal immunized with cells or cell components of Streptococcus mutans. The dental caries-preventive composition inhibits the formation of dental plaque and prevents dental caries. It keeps the antibody stable for a long period of time and hence permits the antibody to exhibit its effect with certainty over a long period of time.

Dental caries-preventive composition containing antibody

A caries-preventive composition comprises an antibody obtained by immunizing a mammal with at least one antigen selected from the group consisting of Streptococcus mutans, its cell-wall fraction, fibrous substance fraction, glucosyltransferase fraction and protein antigen fraction, and a synergist selected from the group consisting of fluorine compounds, chlorhexidine and its salts, lytic enzymes, bacteriocins, glucosyltransferase inhibitors, proteases and dextranases.

Caries-preventive composition

There is provided an oral composition containing a hydroxamic acid represented by the formula R--CH.sub.2 --CO--NHOH (where R is an alkyl group or alkoxyphenyl group) or a salt thereof such as 2-(4-butoxyphenyl)acetohydroxamic acid, 2-(4-methoxyphenyl)acetohydroxamic acid, caprylohydroxamic acid, or laurohydroxamic acid. The oral composition prevents Streptococcus mutans from colonizing in the oral cavity and is effective in preventing dental caries and also in preventing and remedying periodontal disease.

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Kanagawa, Japan

Tsuneo Miyahara