Kanebo, Limited

Tsuneo Kawashima

Goro Tsukamoto

Keizo Ito

Takashi Nose

Ryuichi Iemura

Toshikazu Fukuda

Hiroshi Nakagawa

Minoru Sakaguchi

Norio Awata

Disclosed is a vaginal suppository comprising a pharmaceutically acceptable salt of dehydroepiandrosterone sulfate (hereinafter referred to as DHAS), an amino acid and a hard fat having a hydroxy value of not more than 50. This suppository features an improved absorption of the active drug from the vagina plus a good shelf life.

Vaginal suppository

Novel benzimidazole derivatives of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group, a lower alkenyl group or a lower alkynyl group, R.sup.2 is hydrogen atom, a lower alkyl group or a lower hydroxyalkyl group, and n is 2 or 3, or a pharmaceutically acceptable acid addition salt thereof, which have potent antihistaminic activity with less toxicity and hence are useful as an antihistaminics, and a process for the preparation of the compounds, and a pharmaceutical composition useful as antihistaminics containing the compound as an essential active ingredient.

1-substituted-2-(piperazinyl or homopiperazinyl)-benzimidazole compounds

Novel benzimidazole derivatives of the formula: ##STR1## wherein R.sup.1 is an alkyl group having 1 to 3 carbon atoms, allyl group, propargyl group, or phenyl group; R.sup.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; and n is 2 or 3, or pharmaceutically acceptable acid addition salts thereof, which have excellent antihistaminic activities and are useful as antiallergics for various allergic diseases, and a process for the preparation thereof, and an antihistaminic composition containing the compound as an active ingredient.

Benzimidazole derivatives, process for the preparation thereof and

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Osaka, Japan

Tsuneo Kawashima