Mitsui Chemicals, Inc.

Mitsui Toatsu Chemicals, Incorporated

Schering Aktiengesellschaft

Bayer Schering Pharma Ag

National Institutes of Biomedical Innovation, Health and Nutrition

Savid Therapeutics Inc.

Bayer Intellectual Property Gmbh

Tsuneji Suzuki

Tomoyuki Ando

Katsutoshi Tsuchiya

Eishi Tanaka

Yoshinori Shiraishi

Osamu Nakanishi

Akiko Saito

Takashi Yamashita

Nobuyuki Fukazawa

Hirofumi Tanaka

Yasuhisa Kayaba

Shoko Ono

Kengo Otsuka

Kazuo Kohmura

Takashi Tsuruo

Makoto Odate

Wakao Sato

Akira Awaya

Shigeru Mio

Joji Kamiya

Takafumi Kitano

Hidetoshi Tsunoda

Masahiko Maruyama

Makoto Hirayama

Toshihiko Ito

Tsuyoshi Inoue

Masayuki Furuya

Masaru Wada

Hajime Iizuka

Shinichi Banba

Yoshiyuki Totani

Nobuya Kawauchi

Akinori Nagatomo

Takaomi Hayashi

Hironori Komatsu

Koji Inoue

Hiroko Wachi

Naritoshi Yoshimura

Hiroki Ishibashi

Yuki Nakajima

Kazuhiko Togashi

Kunio Sannohe

Hideo Kitagawa

Kosuke Mano

Masahiko Ishibashi

Taisuke Nakayama

Hiroki Akiba

Kouhei Tsumoto

Ikuo Sakai

Masahiro Sakabe

Sannohe, Kunio

Haruhiko Kamada

Tsuchiya Katsutoshi

Finding a protein of a minute amount present on a cell membrane to provide a method for producing an antibody against the protein. Producing an antibody using a protein identified by an identification method including: a labeling step of using a labeling agent comprising at least one selected from bis-iminobiotin compounds and bis-biotin compounds to obtain cells having a labeled protein; a degradation step of preparing a degradation product for an immobilization treatment, the degradation product containing the labeled protein; an immobilization step of immobilizing the labeled protein contained in the degradation product for an immobilization treatment on a stationary phase via a streptavidin mutant; a cleavage step of releasing an analysis sample from the stationary phase on which the labeled protein is immobilized; and an analysis step of analyzing the analysis sample to identify the labeled protein.

Method for identifying drug-discovery target protein for development of antibody drug, and method for producing antibody against target protein

The invention provides a sealing composition including: polymer (A) containing a cationic functional group and having a weight average molecular weight of from 2,000 to 1,000,000; and a benzotriazole compound; in which the content of the polymer (A) is from 0.05 parts by mass to 0.20 parts by mass with respect to 100 parts by mass of the sealing composition; in which the content of the benzotriazole compound in the sealing composition is from 3 ppm by mass to 200 ppm by mass; and in which the sealing composition has a pH of from 3.0 to 6.5.

Sealing composition and method of manufacturing semiconductor device

Provided is a method for manufacturing a composite body, the method containing: a composition preparation process of preparing a composition that contains a polymer having a cationic functional group and having a weight average molecular weight of from 2,000 to 1,000,000, and that has a pH of from 2.0 to 11.0; a composite member preparation process of preparing a composite member that includes a member A and a member B, a surface of the member B having a defined isoelectric point, and that satisfies a relationship: the isoelectric point of a surface of the member B&#x3c; the pH of the composition&#x3c;the isoelectric point of a surface of the member A; and an application process of applying the composition to the surface of the member A and the surface of the member B included in the composite member.

Method for manufacturing composite body and composition

A method for manufacturing a semiconductor device including: a process of applying a sealing composition for a semiconductor to a semiconductor substrate, to form a sealing layer for a semiconductor on at least the bottom face and the side face of a recess portion of an interlayer insulating layer, the sealing composition including a polymer having a cationic functional group and a weight average molecular weight of from 2,000 to 1,000,000, each of the content of sodium and the content of potassium in the sealing composition being 10 ppb by mass or less on an elemental basis; and a process of subjecting a surface of the semiconductor substrate at a side at which the sealing layer has been formed to heat treatment of from 200&#xb0; C. to 425&#xb0; C., to remove at least a part of the sealing layer.

Semiconductor device, method for manufacturing the same, and rinsing liquid

In the invention, a sealing composition for a semiconductor is provided which includes a polymer that includes two or more cationic functional groups including at least one of a tertiary nitrogen atom or a quaternary nitrogen atom, that has a weight average molecular weight of from 2,000 to 1,000,000, and that has a branching degree of 48% or more, wherein a content of sodium and a content of potassium in the sealing composition are each 10 ppb by weight or less on an element basis.

Sealing composition for semiconductor, semiconductor device and method of producing the same, and polymer and method of producing the same

Provided is a method for producing catechol in a one-pot by reacting (4S,5R,6S)-4,5,6-trihydroxy-2-cyclohexene-1-one under hydrogen-reducing conditions while heating.

Method for producing catechol

A method of treating a malignant tumor selected from the group consisting of leukemia, colorectal cancer, ovarian cancer, oral cancer, lung carcinoma, breast carcinoma, prostate carcinoma, and melanoma by administering to a patient in need thereof an effective amount of at least one compound represented by formula (1) wherein A, X, Q, R, and n are defined herein.

Cell differentiation inducer

The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma. 

A glycoside in which at least two phenolic hydroxyl groups of a compound having at least two phenolic hydroxyl groups in its molecule are glycosidically linked to anomeric carbon atoms of at least two sugar molecules can be prepared with high yield by a method including the step of allowing phenolic hydroxyl groups of a compound having at least two phenolic hydroxyl groups in its molecule to react with sugar molecules each having an acetylated hydroxyl group attached to an anomeric carbon atom in the presence of an organic solvent and an acid catalyst while removing acetic acid formed during the reaction from the reaction system.

Process for producing glycoside

The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.

Cell differentiation inducer, benzamide compounds

A method for producing an optically active 2-phenyl-2,3,-dihydroxypropyl azole derivative, which is a useful compound in various fields. An optically active &#x3b1;-hydroxycarboxylic acid derivative represented by general formula (1) is used as a starting material and is allowed to react with an azole acetic acid derivative (2) to produce a new, optically active azole-alkyl ketone derivative (3). Subsequently, a new, optically active azole-methyl alcohol derivative (5) is produced by highly diastereoselective alkylation by an appropriate combination of a protective group and an organometallic reagent (4). Furthermore, the optically active azole-methyl alcohol derivative (5) is selectively deprotected to produce an optically active 2-phenyl-2,3-dihydroxypropyl azole derivative (6) 

Optically active azole derivative and process for producing the same

Benzamide derivatives and pharmaceutical compositions containing same

A novel method has been found to produce 2,2'-anhydro-1-(&#x3b2;-L-arabinofuranosyl)thymine as a novel useful intermediate compound. A novel method has been further found to produce thymidine from 2,2&#x2032;-anhydro-1-(&#x3b2;-L-arabinofuranosyl)thymine. A novel method has been further found to L-2&#x2032;-deoxyribose derivatives as a useful synthetic intermediate through L-2,2&#x2032;-anhydro-5,6-dihydrocyclouridine derivative. According to these methods, synthesis of various L-nucleic acid derivatives, synthesis of which has been difficult till now.

L-nucleic acid derivatives and process for the synthesis thereof

Growing community of inventors

Chiba, Japan

Tsuneji Suzuki