Mitsubishi Chemical Corporation

Mitsubishi Kasei Corporation

Tsunehiko Kurata

Junya Watanabe

Hideaki Kiniwa

Masaru Sano

Jun Haginaka

Takashi Nishikaji

A composition useful for separating lipoproteins, such as high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and modified lipoproteins with a high degree of accuracy by ion-exchange based procedures. The composition comprises an organic particle having a hydrophilic surface onto which ion-exchange groups are introduced and which is formulated so as to provide a high enough degree of hydrophilicity to prevent irreversible absorption of lipoproteins, but which is not so high as to block the pores of the ion exchange particles and prevent adequate retention and separation of lipoproteins. A method for making a composition for separating lipoproteins comprising seed polymerization of organic particles, hydrophilic treatment of the organic particles by introducing 0.1-45% of a compound (B) having a cyclic ether group and/or a hydrophilic group and a polymerizable unsaturated double bond into organic polymer particles (A) by an addition reaction, and copolymerizing with the addition product of (A) and (B) 5-60% of a polymerizable vinyl monomer (C) having a cyclic ether group or/and a hydrophilic group to form particles (D) having a hydrophilic surface, and introducing an ion exchange group in an amount ranging from 0.15 milliequivalent or less per 1 g of dry particles (D).

Ion exchanger for lipoproteins separation and lipoproteins separation method using the same

A method for producing a spherical crosslinked copolymer, which comprises polymerizing a monofunctional addition-polymerizable monomer and at least 0.5% by weight of a polyfunctional addition-polymerizable monomer on the basis of the total weight of monomers by suspension polymerization in an aqueous medium in the presence of a radical polymerization initiator of the following formula (b) which has a decomposition temperature for a half-life period of 10 hours within a range of from 60.degree. to 120.degree. C. and which is capable of forming at least four radical initiating points per molecule by the decomposition:

Method for producing a spherical ion exchange resin

An adsorbent for optical resolution obtained by graft polymerizing an optically active vinyl monomer of the formula: ##STR1## wherein X is --CONH--, --COO-- or --NHCOO--, R.sup.1 is a hydrogen atom or a methyl group, and each of R.sup.2 to R.sup.4 which are different from one another, is a hydrogen atom, a hydrocarbon group or an alkoxycarbonyl group, or R.sup.2 and R.sup.3 together form a ring, to a crosslinked polymer carrier having groups to which said monomer is graft polymerizable.

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Yokohama, Japan

Tsunehiko Kurata