The University of Tokyo

Nagoya City University

Tsunehiko Higuchi

Tetsuo Nagano

Hirotatsu Kojima

Hidenori Ichijo

Yusuke Wataya

Takayoshi Okabe

Hye-Sook Kim

Takao Fujisawa

Naoki Umezawa

Kengo Homma

Norio Shiibata

Seiichi Nakamura

Naomi Tsuburaya

Hidehiko Nakagawa

Shin-Ichi Ikeda

Manabu Shimonishi

Hirohisa Omiya

A compound represented by the following formula (1) is provided: wherein X represents a sulfur atom or &#x2014;CH&#x2550;CH&#x2014;; Ato Aeach independently represent a carbon atom or a nitrogen atom, and at least one of Ato Ais a nitrogen atom; Rrepresents any one of a 1,2,3,4-tetrahydroquinolyl group (or a 3,4-dihydro-1(2H)-quinolyl group), a 3,4-dihydro-4,4-dimethyl-1(2H)-quinolyl group, a 2,3,4,5-tetrahydro-1H-1-benzazepinyl group, or a substituent represented by the following formula (2): wherein Rrepresents a 2,3,4-trifluorophenyl group, a 4-iodophenyl group, a 2,3-difluorophenyl group, a 3,5-difluorophenyl group, a 5-fluoro-2-methylphenyl group, a 3-pentafluorosulfanylphenyl group, a 2,6-dimethylphenyl group, a 4-benzyloxyphenyl group, a 3,5-bis(trifluoromethyl)biphenyl group, a 4-tert-butylphenyl group, a 3-methoxyphenyl group, an unsubstituted or substituted pyridyl group, or an unsubstituted or substituted naphthyl group; Rrepresents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group optionally containing an oxygen atom and/or a double bond, or an unsubstituted or substituted aromatic lower alkyl group; Rrepresents a hydrogen atom, a lower alkyl group, a lower acyl group, or an unsubstituted or substituted aromatic lower alkyl group; and Rrepresents a hydrogen atom, or Rand Rmay bind to each other to form a ring.

Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof

Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein Ris H, Cl or OCH; Ris H or CH; Ris CH, CH, C(CH), CH(CH) or C(CH); Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.

Compound with antimalarial activity and antimalarial drug containing the same as active ingredient

Growing community of inventors

Nagoya, Japan

Tsunehiko Higuchi