Okayama University

Ensuiko Sugar Refining Co., Ltd.

Hiroki Hamada

Yoshio Shimizu

Tsukasa Shigehiro

Katsuhiko Mikuni

Masaharu Seno

Tomonari Kasai

Ichiro Fujiwara

Masaharu Murakami

In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water.

Method for producing liposome encapsulating paclitaxel monoglycoside and/or docetaxel monoglycoside

Growing community of inventors

Okayama, Japan

Tsukasa Shigehiro