Gunze Limited

Tsuguyoshi Taira

Yoshito Ikada

Shojiro Matsuda

Yuki Sakamoto

Shinichiro Morita

Toshiharu Shinoka

Shigehiko Suzuki

Kenji Tomihata

Goki Matsumura

Yoshitake Takahashi

Hitoshi Otani

Noriyuki Morikawa

The present invention provides a tissue regeneration substrate that has the ability to release a basic fibroblast growth factor (bFGF) and like cell growth factors in a sustained manner, into which cells can easily enter, and that is suitably used for regeneration of tissues. Specifically, the present invention provides a tissue regeneration substrate that comprises a cell growth factor adsorbed in a bioabsorbable porous substrate that contains collagen and gelatin, and a method for producing the same.

Tissue regeneration substrate

An object of the present invention is to provide an anti-adhesion membrane that has no toxicity to a living body, has flexibility allowing itself to fit an affected part as a hydrated gel, is uniformly crosslinked, and is immediately absorbed in a living body after maintaining its shape in the living body for a certain period of time. The present invention provides anti-adhesion material, which comprises a thermally crosslinked gelatin film, and has a water content of 60 to 85% calculated by the following formula (1):water content (%)=[()/]&#xd7;100(%)&#x2003;&#x2003;(1),in the formula (1), Ws representing a weight (wet weight) of the anti-adhesion material immersed in a phosphate buffered saline solution at a temperature of 25&#xb0; C. for one hour, and Wd representing a weight (dry weight) of the anti-adhesion material dried completely using a vacuum drying apparatus.

Anti-adhesion membrane

The scaffold for culturing a cardiovascular tissue of the present invention is a scaffold for culturing a cardiovascular tissue, which is tubular, and comprises a foamed polymer comprising a bioabsorbable material reinforced with a reinforcing material comprising a bioabsorbable material, the foamed polymer comprising lactide (D, L, DL isomer)-&#x3b5;-caprolactone copolymer containing lactide (D, L, DL isomer) in a content of 50 to 54 mole % and &#x3b5;-caprolactone in a content of 50 to 46 mole %, and the reinforcing material being covered with the foamed polymer.

Substrate for culture of cardiovascular tissue

The invention provides an artificial dura mater comprising a sheet made of bioabsorbable synthetic polymers formed from copolymers of lactic acid and .epsilon.-caprolactone.

Artificial dura mater

Growing community of inventors

Ayabe, Japan

Tsuguyoshi Taira