Nippon Kayaku Kabushiki Kaisha

Takara Shuzo Co., Inc.

Takara Shuzo Kabushiki Kaisha

Tsugio Tomiyoshi

Yoshihisa Umeda

Tetsushi Saino

Kyuichi Nemoto

Seiichi Saito

Takashi Harada

Masashi Nagai

Tomio Morino

Takaaki Nishikiori

Takamichi Sato

Takeji Sakasai

Takako Mae

Keiko Watanabe

Atsushi Kuwahara

Tetushi Saino

A novel cystacycline derivative which has an excellent effect of promoting the differentiation of neurons and is useful as a remedy for central nervous system disorders, a remedy for peripheral nerve disorders, etc.

Compound having effect of promoting neuron differentiation

Novel spergualin-related compounds represented by the general formula (I): ##STR1## wherein X represents --(CH.sub.2).sub.1-5 -- or a phenylene group which may be substituted; m represents 0, 1 or 2; n represents 1 or 2; and R.sub.1 represents --(CH.sub.2).sub.1-3 --COOH, and pharmacologically acceptable salts thereof, possess an immunopotentiating activity, and are expected to be useful as immunopotentiators applicable to warm blooded animals.

Spergualin-related compound and use thereof

The present invention relates to novel spergualin-related compounds represented by the general formula [I]: ##STR1## wherein X is --(CH.sub.2).sub.1.about.5 or ##STR2## Y is a hydrogen atom or a residue obtained by removing a hydroxyl group from the carboxyl group of an amino acid or a peptide; m is 0, 1 or 2 and n is 1 or 2, with the proviso that Y is not a hydrogen atom when n is 2 and m is 0. This compounds are stable and exhibit a high immunosuppressive activity.

Novel spergualin-related compounds and compositions

The present invention provides a use for the preparation of an immunopotentiator of a spergualin-related compound represented by the following general formula [I] or a pharmacologically acceptable salt thereof: ##STR1## wherein X represents ##STR2## or --(CH.sub.2).sub.n --, Y represents a hydrogen atom or a hydroxyl or hydroxymethyl group,

Immunopotentiator and spergualin-related compound therefor

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Tokyo, Japan

Tsugio Tomiyoshi