Sirigen Ii Limited

Sirigen, Inc.

Industrial Technology Research Institute

Personal Genomics, Inc.

Becton Dickinson and Company Limited

Skigen, Inc.

Tsu-Ju Fu

Brent S Gaylord

Janice W Hong

Russell A Baldocchi

ChengJun Sun

Jenn-Yeh Fann

Shang-Chia Chang

Cheng-Jun Sun

Chung-Fan Chiou

Chao-Chi Pan

Cheng Jun Sun

Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

Fluorescent methods and materials for directed biomarker signal amplification

Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation, resulting in more observable sequencing events and increasing the accuracy of nucleic acid sequencing.

Compositions and methods for sequencing nucleic acids

This invention is to describe nucleotide analogs used in a method for the determination of a nucleic acid sequence. The method involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.

Nucleotide analogs for real-time sequencing method for single molecule

This invention is to describe a method for the determination of a nucleic acid sequence, in which it involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.

Real-time sequencing method for single molecule

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Tsu-Ju Fu