Biocryst Pharmaceuticals, Inc.

Tsu-Hsing Lin

Pooran Chand

Yarlagadda Sudhakara Babu

Pravin L Kotian

V Satish Kumar

Minwan Wu

Yahya El-Kattan

Ajit K Ghosh

R Scott Rowland

Methods for the preparation of the &#x3b2; isomer of a 9-deazapurine derivatives using benzyl protecting groups as the protecting groups for the 2 and 3 hydroxyl groups in ribose are provided.

Methods for the preparation of 9-deazapurine derivatives

The invention provides methods for treating hepatitis C viral infections and related viral infections, as well as compounds and compositions that are useful for treating such infections.

Hepatitis C therapies

The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.

Therapeutic furopyrimidines and thienopyrimidines

Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas:

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Vestavia Hills, AL, United States of America

Tsu-Hsing Lin