Agency for Science, Technology and Research

Tseng-Ming Hsieh

Jackie Yi-Ru Ying

Pavel Neuzil

Juergen Hans Pipper

Guolin Xu

Chunyan Zhang

Yoke San Daniel Lee

Shyi-Herng Kan

Emril Mohamed Ali

Jeremy Ming Hock Loh

Mo-Huang Li

Jackie Y Ying

Juergen Pipper

According to various embodiments, a reagent fluid dispensing device may be provided. The reagent fluid dispensing device may include a chamber for receiving a reagent fluid, the chamber having a first opening and a second opening; a first fluid conduit connected to the first opening of the chamber; a reservoir connected to the first fluid conduit, the reservoir having a first opening, wherein the first opening of the reservoir is connected to the first fluid conduit to form a passive valve, wherein the reservoir is dimensionalized for storing a predetermined volume of the reagent fluid; and a pneumatic conduit connected to the second opening of the chamber, wherein selective application of pneumatic pressure to the chamber through the pneumatic conduit transfers the reagent fluid from the reservoir to the chamber through the first fluid conduit. According to various embodiments, a microfluidic device including the reagent fluid dispensing device, and a method of dispensing a reagent fluid may be provided.

Reagent fluid dispensing device, and method of dispensing a reagent fluid

Apparatus for conducting and monitoring chemical reactions comprises a base and a thermal cycler mounted on the base. A plurality of heat-conducting receptacles are mounted on the thermal cycler and in heat-communication therewith. Each receptacle comprises an opaque body defining a bore having an open end, a first window, and a second window. A cartridge is removably mounted on the receptacles. The cartridge comprises a plurality of light-transmitting reaction vessels, and conduits connected to the reaction vessels for processing and transferring fluid. The reaction vessels are received in the bores of the receptacles through the open ends of the bores. A light emitter is mounted on the base for illuminating the reaction vessels through the first windows of the reaction vessels. A light detector is mounted on the base for selectively receiving and detecting light emitted from the reaction vessels through the second windows of the receptacles.

Integrated apparatus for conducting and monitoring chemical reactions

The invention provides a method of processing a biological and/or chemical sample. The method includes providing a fluid droplet, which includes an inner phase and an outer phase. The outer phase is immiscible with the inner phase, and the outer phase is surrounding the inner phase. The inner phase includes the biological and/or chemical sample. The fluid droplet furthermore comprises magnetically attractable matter. The method also includes providing at least one surface, which is of such a texture and such a wettability for the fluid of the inner phase of the fluid droplet, that the fluid droplet remains intact upon being contacted therewith. The method further includes disposing the fluid droplet onto the at least one surface. The method also includes performing a process on the biological and/or chemical sample in the fluid droplet.

Method of processing a biological and/or chemical sample

The invention provides an apparatus for regulating the temperature of a chemical and/or biological sample and a method of using the same. The apparatus includes at least one temperature control module. The temperature control module includes a heater, a conductor of caloric, and a temperature sensor. The heater of the temperature control module is adapted to thermally communicate with a removable substrate, on which said chemical and/or biological sample is placed, via the conductor of caloric. The temperature sensor of the temperature control module is adapted to detect and control the temperature of the substrate via the conductor of caloric. The apparatus is designed such that the substrate is situated above said temperature control module to entirely cover said temperature control module.

Apparatus for regulating the temperature of a biological and/or chemical sample and method of using the same

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Singapore, Singapore

Tseng-Ming Hsieh