National Taiwan University

Advpharma, Inc.

University of North Carolina at Chapel Hill

Academia Sinica

National Health Research Institutes

Tse-Ming Hong

Pan-Chyr Yang

Jeremy J W Chen

Yuh-Ling Chen

Yi-Ying Wu

Shuenn-Chen Yang

Yi-Jen Lee

Ang Yuan

Cheng-Chung Wu

Jin-Yuan Shin

Kuo-Hsiung Lee

Che-Ming Teng

Kenneth F Bastow

Qian Shi

Konan Peck

Cheng-Wen Wu

Xiaoming Yang

Jin-Yuan Shih

The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer. 

Antofine and cryptopleurine derivatives as anticancer agents

The present invention provides a cyclic peptide containing RRXR motif. The present invention also provides a composition comprising the said cyclic peptide and a pharmaceutical acceptable carrier. The present invention further provides a method for treating cancer.

Composition for treating cancer and use thereof

This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to enhance the expression of the CRMP-1 and/or a reporter protein. The invention also provides a DNA construct containing this transcription unit which can be transfected into a host cell. Additionally, the invention provides methods to enhance the expression of CRMP-1 and/or the reporter protein. The over-expression of CRMP-1 in a cancer cell can inhibit the metastasis of the cancer cell.

Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences

This invention is based on the discovery of an association of Collapsin Response Mediator Protein-1 (CRMP-1) with tumor metastasis. The level of CRMP-1 protein or mRNA can be used as an indicator of cellular invasiveness and of a test compound's ability to alter cellular invasiveness. The level of CRMP-1 protein can also be altered, e.g., to reduce invasiveness.

Collapsin response mediator protein-1

Growing community of inventors

Taipei, Taiwan

Tse-Ming Hong