Industrial Technology Research Institute

Bio Preventive Medicine Corp.

Tsai-Wei Hsu

Tzu-Ling Tseng

Wei-Ya Lin

Mary Ya-Ping Yeh

Yi-Ting Chen

Ping-Fu Cheng

Hung-Yi Li

Yen-Peng Li

Yuh-Feng Ling

Jin-Shuen Chen

Ching-Fang Lu

Chwei-Shiun Yang

Yuh-Feng Lin

Giien-Shuen Chen

Described is a method of detecting a protein fragment in a urine sample and a serum sample. The protein fragment is a urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, or serum osteopontin fragment. The urine sample and the serum sample are obtained from the same individual.

Method of detecting a urine protein fragment and a serum protein fragment

Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.

Biomarkers associated with nephropathy

Disclosed is use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.

Urine and serum biomarkers associated with diabetic nephropathy

Growing community of inventors

Miaoli County, Taiwan

Tsai-Wei Hsu