The University of Texas System

Dow Global Technolgoies LLC

Rohm and Haas Company

The Dow Chemical Company

Union Carbide Chemicals & Plastics Technology Corporation

True L Rogers

Keith P Johnston

Robert O Williams, Iii

Jason T McConville

Robert Talbert

Jay I Peters

Alan B Watts

Prapasri Sinswat

Timothy J Young

Christopher John Tucker

Meinolf Brackhagen

Roland Adden

Susan L Jordan

Nicholas S Grasman

Brian D Scherzer

James E Hitt

David A Hayes

Jason T Mcconville

Jay Peters

Iii Williams Robert O

David L Malotky

Matthias Knarr

Oliver Petermann

Robert L Schmitt

Mark J Hall

Steven J Guillaudeu

Robert B Appell

Ian B Gillespie

Paula C Garcia

Nicholas S Beck

David S Burgess

Kebede Beshah

Aslin Izmitli

Karen A Coppens

Shari L Workentine

Jaime L Curtis-Fisk

Wesley J Spaulding

Uma Shrestha

Maureen L Rose

Jiahui Hu

Zhongshui Yu

Melisa K Barron

Debora L Holbrook

Kevin P O'donnell

William W Porter, Iii

Robert O Iii Williams

Prapasri Sinwat

The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.

Methods for making compositions for pulmonary administration

Enhanced delivery of immunosuppressive drug compositions for pulmonary delivery

A process to produce a dispersion comprising feeding ethylcellulose polymer and a dispersant into a melt and mix zone of an extruder wherein the ethylcellulose polymer and dispersant are melted and mixed together to form a melt; conveying the melt to an emulsification zone of the extruder in which the temperature and pressure are controlled; feeding a base and water into the emulsification zone wherein the melt is dispersed to form a high internal phase emulsion; conveying the emulsion to a dilution and cooling zone of the extruder; and feeding water into the dilution and cooling zone to dilute the high internal phase emulsion thereby forming an aqueous dispersion is provided.

Process to produce an aqueous dispersion, an aqueous dispersion produced thereby and a coating composition comprising the aqueous dispersion

A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.

Solid dispersion comprising a highly substituted hydroxyalkyl methylcellulose

A composition designed for application to a mucosa comprises a tonicity-adjusting agent, a methylcellulose, and a liquid diluent, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.

Composition for application to a nasal mucosa comprising a methylcellulose

Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (C) of at least about 0.25 &#x3bc;g/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.

Enhanced delivery of drug compositions to treat life threatening infections

A melt-extruded polymer composition comprising a) at least one cellulose ether, b) one or more active ingredients and c) one or more optional additives, wherein said at least one cellulose ether has an MS (hydroxyalkyl) of 0.05 to 0.55 and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26&#x2212;0.2*MS(hydroxyalkyl)] is 0.32 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

Melt-extruded composition comprising a cellulose ether

The present disclosure is directed to cellulose ether compositions for film-forming coating applications. A coating composition is provided which contains an aqueous solution of either a very low viscosity cellulose ether or a low-hydroxypropyl cellulose ether, the coating composition having low color, The low viscosity of the cellulose ether component enables the coating composition to contain a high concentration of cellulose ether. Provision of these high concentration cellulose ether coating solutions improves production efficiency by reducing the time required to coat a substrate.

Cellulose ether coating compositions and method

The present invention provides a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased porosity and a more intimate mixing of the particle components. The system and method of the present invention also produce particles with greater surface area than conventional methods. One form of the present invention provides a method for the preparation of particles. An effective ingredient is mixed with water, one or more solvents, or a combination thereof, and the resulting mixture is sprayed through an insulating nozzle located at or below the level of a cryogenic liquid. The spray generates frozen particles.

Process for production of nanoparticles and microparticles by spray freezing into liquid

Growing community of inventors

Midland, MI, United States of America

True L Rogers