Novartis Ag

Ocusoft, Inc.

Astex Therapeutics Limited

Troy Douglas Smith

Zhuoliang Chen

Martin Sendzik

Matthew J LaMarche

Jorge Garcia Fortanet

Lawrence Blas Perez

Rajesh Karki

Bakary-Barry Toure

Mitsunori Kato

Sarah Williams

Christine Hiu-Tung Chen

John William Giraldes

Michael Dore

Michael David Shultz

Fan Yang

Nat Adkins, Jr

Yue Ping Li

Miles Stuart Congreve

Steven Howard

Julien Papillon

Bharat Lagu

Gilbert Besong

Christopher Thomas Brain

Gang Liu

Qian Zhao

James Clifford Sutton

Keith Bruce Pfister

Cynthia Shafer

Mark G Palermo

Moo Je Sung

Bing Yu

Mark Gabriel Palermo

Guo He

Dyuti Majumdar

Katsumasa Nakajima

Claudio Dagostin

Wojciech Wrona

Paramita Sarkar

Yipin Lu

Paul Mortenson

Ying Hou

Christopher Adair

Clinton Alan Brooks

Michael Scott Visser

Christopher Sean Straub

Jianmei Fan

Julian Roy Levell

Steven John Woodhead

Leigh Zawel

Atwood Kim Cheung

Abran Q Costales

Yaping Wang

Sushil Kumar Sharma

Donovan Noel Chin

Young Shin Cho

Run-Ming David Wang

Ronald Charles Tomlinson

Steven Woodhead

Jeffrey T Bagdanoff

Huangshu Lei

Francois Lenoir

Karen Marie Miller-Moslin

Thomas Raymond Caferro

Patrick James Sarver

Nat Adkins

Rukundo Ntaganda

Brandon Sands

Seema Nanda

Matthew J Lamarche

Moo Sung

Misunori Kato

Clinton A Brooks

Yue Li

A composition for treating dry skin includes therapeutically active concentrations of one or more skin protecting lipids in an oleaginous base. The skin protecting lipids can include a sphingolipid and at least one oil. The composition is intended for application on the skin surrounding the eyes. The composition is configured to form a protective, occlusive layer that can moisturize the skin and reduce inflammation and itching without stinging, burning, or stripping the skin. According to an exemplary embodiment, the composition is formulated as a high viscosity ointment or gel.

Ointments for treating dry skin

A method of preparing compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein Rthrough Rare as defined herein.

Urea compounds and compositions as SMARCA2/BRM ATPase inhibitors

The present invention relates to compounds of formula I:

N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a BRM-mediated and/or BRG1-mediated disease or disorder: Formula (I) wherein Rthrough Rare as defined herein.

Compounds and compositions for inhibiting the activity of SHP2

The invention involves forceps having rounded grasping tips. The rounded tips are configured to avoid puncturing an amniotic membrane during insertion over an ocular surface for the treatment of dry eye disease and inflammation of the eyes and to avoid injuring the conjunctiva during removal of an amniotic membrane from the ocular surface. The forceps have grasping tips at its distal end, wherein one of the grasping tips has a notch on its inside surface. The dimensions of the notch are configured to permit an eye doctor to securely and safely grasp a lip of an amniotic membrane insert for better insertion and removal from an ocular surface.

Forceps

Compositions and methods for treating skin redness. According to an embodiment, the invention is a topical skin care composition having a dermatologically acceptable vehicle, such as, water and a plurality of ingredients dissolved in the vehicle. The ingredients include: a blend of natural oils; a plurality of vitamins; and 0.1-1 wt % salicyloyl phytosphingosine. The composition is unsuitable for application on the eyelids or eye area. The blend of natural oils includes:leaf juice extract;(coconut oil); hydrolyzed glycosaminoglycans; and caprylic/capric triglycerides. The plurality of vitamins is selected from a group consisting of vitamin C, vitamin E, salts/derivatives of vitamin C and vitamin E, and mixtures thereof. In one aspect, the plurality of vitamins includes: sodium ascorbyl phosphate; disodium lauriminodipropionate tocopheryl phosphate; and jojoba oil.

Topical skin care compositions

Systems, methods, and kits useful for cleansing the eyelids and maintaining eyelid hygiene are disclosed. In one embodiment, a system for treating or cleansing an ocular region is disclosed. The system consists essentially of: (A) a tubular applicator, wherein the applicator comprises: (i) a first chamber and a second chamber; and (ii) a sealable element situated between the first chamber and the second chamber, wherein at least the second chamber is substantially pre-filled with an ocular composition, and (B) a dispenser, wherein the dispenser is bonded to an external surface of a first end of the applicator.

Systems, methods and kits for cleansing an ocular region

The present invention relates to compounds of formula I: 

The present invention relates to compounds of formula I: in which p, q, Y, Y, R, R, R, R, R, R, R, R, R, Rand Rare defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

An anti-allergenic composition comprising from about 0.01% to about 50% by weight of a polyphenol, from about 0.01% to about 50% by weight of a terpene compound, and from about 0.001% to about 10% by weight of a glycolipid. The polyphenol has a flavanol derivative. The terpene compound can be selected from the group consisting of a terpene, terpinene, a terpene derivative and combinations thereof. In an embodiment, the sphingolipid comprises about 0.2% phytosphingosine.

Anti-allergenic ocular compositions and eyelid cleansing wipes

The present invention relates to compounds of formula I: in which Y, Y, R, Rand Rare defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2. 

Compositions and methods for treating skin redness. According to an embodiment, the invention is a topical skin care composition having a dermatologically acceptable vehicle, such as, water and a plurality of ingredients dissolved in the vehicle. The ingredients include: a blend of natural oils; a plurality of vitamins; and 0.1-1 wt % salicyloyl phytosphingosine. The composition is unsuitable for application on the eyelids or eye area. The blend of natural oils includes: aloe barbadensis leaf juice extract; cocos nucifera (coconut oil); hydrolyzed glycosaminoglycans; and caprylic/capric triglycerides. The plurality of vitamins is selected from a group consisting of vitamin C, vitamin E, salts/derivatives of vitamin C and vitamin E, and mixtures thereof. In one aspect, the plurality of vitamins includes: sodium ascorbyl phosphate; disodium lauriminodipropionate tocopheryl phosphate; and jojoba oil.

Growing community of inventors

Nashua, NH, United States of America

Troy Douglas Smith