Photocure Asa

Photocure as

Oslo Universitetssykehus Hf

3Skin as

Trond Warloe

Qian Peng

Johan E Moan

Harald Steen

Karl E Gierskcky

Alf Bjorseth

Alf Bjørseth

Jahn M Nesland

Jo Klaveness

Aslak Godal

Nils Olav Nilsen

Jon Erik Braenden

Toril Holien

Odrun Arna Gederaas

Eidi Christensen

Karl E Giercksky

Ana Soler

Johan Moan

Karl Erik Gierskcky

The present invention relates to the use of a photoactivatable Porphyrin-Derivative in extracorporeal photophoresis (ECP) treatment, in which a patient's blood or part of it containing sad Porphyrin-derivative is/are exposed to light of a wavelength which activates said photoactivatable Porphyrin-Derivative.

Modification of extracorporeal photopherisis technology with porphyrin precursors

The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) RN&#x2014;CHCOCH&#x2014;CHCO&#x2014;OR(wherein Rmay represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and Rrepresents a hydrogen atom or a group R, and both Rgroups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N&#x2014;CH2COCH2-CH2CO&#x2014;OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy

The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N&#x2014;CH2COCH2&#x2014;CH2CO&#x2014;OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

The present invention provides a compound of formula I;RN&#x2014;CHCOCH&#x2014;CHCO&#x2014;OR&#x2003;&#x2003;(I)wherein Rrepresents (a) an optionally substituted branched Calkyl group, comprising a straight chain Calkyl group, branched by substitution with one or more Calkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more &#x2014;O&#x2014;, NR&#x2014;, &#x2014;S&#x2014; or PR&#x2014; groups; R, each of which may be the same or different, represents a hydrogen atom or a group R, wherein Rrepresents (a) an optionally substituted branched Calkyl group, comprising a straight chain Calkyl group, branched by substitution with one or more Calkyl groups, wherein said site of substitution is at C2 or a higher C atom, (b) a non-heteroaromatic aryl substituted alkyl group, wherein said aryl group is substituted, or (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, wherein in (a) and (b) said substituents are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups, and said alkyl group is optionally interrupted or terminated by one or more &#x2014;O&#x2014;, NR&#x2014;, &#x2014;S&#x2014; or PR&#x2014; groups; and Rrepresents a hydrogen or Calkyl group, and salts thereof for use in photochemotherapy or diagnosis. Pharmaceutical compositions comprising said compound, methods of diagnosis or photochemotherapy using said compound and related compounds and compositions, and products and kits comprising said compounds are also provided.

The invention provides pharmaceutical compositions comprising a protoporphyrin precursor photochemotherapeutic agent together with vascular stroma-localizing photosensitizers, optionally together with at least one surface penetration assisting agent and optionally with one or more chelating agents, and use of the same in treating disorders or abnormalities which are responsive to PDT, preferably exhibiting synergistically enhanced therapy, kits comprising same and methods of therapy and diagnosis.

Photochemotherapeutic compositions

The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R N&mdash;CH COCH &mdash;CH CO&mdash;OR (wherein R may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R represents a hydrogen atom or a group R , and both R groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.

Esters of 5-aminolevulinic acid as photosensitizing agents in

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Oslo, Norway

Trond Warloe