Novartis Ag

Nektar Therapeutics

Trixie Tan

Danforth Miller

Jeffry G Weers

Thomas E Tarara

Daniel Huang

David Lechuga-Ballesteros

Sarvajna Kumar Dwivedi

Nagaraja P Rao

Michael A Eldon

Keith Washco

Sarma Duddu

Alan Kugler

Theresa D Sweeney

Srinivas Palakodaty

Richard Malcolmson

Christopher Frantz

Embodiments of the invention relate to particulate agents and compositions comprising particulate agents for inhalation, and methods for preparing such particulate agents and compositions for inhalation, as well as therapeutic methods. Embodiments of the method comprise preparing an emulsion by combining an oil phase dispersion of hydrophobic seed particles and an aqueous dispersion comprising an emulsifier and an emulsion stabilizer and preparing a feedstock comprising encapsulated particles by homogenizing the emulsion, and forming a plurality of coated particles by spray drying the feedstock, wherein resulting particles comprises a porous shell disposed on or over a core and the core comprises at least one hydrophobic seed particle.

Spray-dried solid-in-oil-in-water dispersions for inhalation of active pharmaceutical ingredients

A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 &#x3bc;m to about 1.9 &#x3bc;m. Another composition also includes particles including at least about 95 wt % of amphotericin B, wherein at least about 80 wt % of the particles have a geometric diameter ranging from about 1.1 &#x3bc;m to about 1.9 &#x3bc;m. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 &#x3bc;m, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.

Compositions comprising amphotericin B, methods, and systems

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Belmont, CA, United States of America

Trixie Tan