Boehringer Ingelheim International Gmbh

Novartis Ag

Boehringer Ingelheim Pharma Gmbh & Co Kg

Novartis Pharma Gmbh

Trixi Brandl

Matthias Grauert

Matthias Hoffmann

Steffen Breitfelder

Christoph Hoenke

Stefan Scheuerer

Prakash Raman

Oliver Simic

Pascal Rigollier

Mohindra Seepersaud

Alexander Pautsch

Martin Steegmaier

Michael Paul Pieper

Ingo Pragst

Michael A Patane

Jiping Fu

David Thomas Parker

Aregahegn Yifru

Rui Zheng

Flavio Solca

Christian Eickmeier

Rudolf Hauptmann

Darryl McConnell

Anke Baum

Steffen Steurer

Andreas Schoop

Riccardo Giovannini

Armin Heckel

Georg Dahmann

Stefan Peters

Gerald Juergen Roth

Gerhard Schaenzle

Frank Hilberg

Dirk Kessler

Bodo Betzemeier

Gisela Schnapp

Sara Frattini

Stefanie Flohr

Enzo Cereda

Richard Sedrani

John Edward Park

Robert Epple

Udo Maier

Anne T Joergensen

Klaus Erb

Branko Radetich

Francois Lenoir

Ulrike Weyer-Czernilofsky

Maria Impagnatiello

Florian Colbatzky

Irene Waizenegger

Bernd Krist

Christian Klein

Thomas Gerstberger

Ralph Brueckner

Andreas Zoephel

Matthias Hoffman

Michael Gmachl

Charlotte Reither

Norbert Schweifer

Oliver Simon

Frank Buettner

Eckhart Bauer

Thomas Zoller

Jens Juergen Quant

Christian Markert

Juraj Velcicky

Jens Jurgen Quant

Kenji Namoto

Monica Quai

Frank Kalkbrenner

Gerhard Schaenze

Martin Renatus

Sebastian Kopec

Julie Lachal

Perle Nganga

Bernard Pirard

Nveed Chaudhary

Anne Joergensen

Frank Büttner

Gerald Jürgen Roth

Claus Ehrhardt

The present invention relates to the use of indolinones of general formula 

Medicaments for the treatment or prevention of fibrotic diseases

The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.

N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides

The present application describes organic compounds of Formula (II) that are useful for the treatment, prevention and/or amelioration of human diseases.

Organic compounds and their uses

The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

Peptidomimetic sulfamide compounds and antiviral uses thereof

Derivatised proline containing peptide compounds as protease inhibitors

The present invention provides a method of treating a HCV infection in a subject in need thereof by administering a compound of Formula I: or pharmaceutically acceptable salts thereof or stereoisomers thereof.

New compounds of Formula (1) are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney. 

Pteridinone derivatives as PI3-kinases inhibitors

The present invention relates to compounds of general formula (I), wherein the groups A, R, R, Rand Rhave the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-quinazolines and the use thereof as pharmaceutical compositions.

Thiazolyl-dihydro-quinazolines

Disclosed are thiazolyl-dihydro-quinazolines of general formula (I) wherein the groups Rto Rhave the meanings given in the claims and specification, the isomers thereof, and processes for preparing these compounds and their use as pharmaceutical compositions.

Thiazolyl-dihydro-quinazoline compounds and processes for preparing same

New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.

Inhibitors of PI3-kinases

The present application describes organic compounds of the Formula I that are useful for the treatment, prevention and/or amelioration of human diseases. 

The present invention encompasses compounds of the general formula (1) in which

Thiazolyl-dihydro-indazoles

Disclosed are pyridodihydropyrazinone compounds, processes for preparing them and their use as pharmaceutical compositions. The compounds according to the invention correspond to general formula (I), while the groups L, R, R, R, Rand Rmay have the meanings given in the claims and specification.

Methods of using pyridodihydropyrazinones

Growing community of inventors

Basel, Switzerland

Trixi Brandl