Bayer Aktiengesellschaft

Miles Laboratories, Inc.

Miles Inc.

Trevor S Abram

Peter Norman

Graham Sturton

Mazen Es-Sayed

Stephen Richard Tudhope

Mary F Fitzgerald

Ulrich Rosentreter

Rudolf H Hanko

Rudiger Fischer

Gabriele Braunlich

Harold C Kluender

Steven R Tudhope

Wendy J McDonald-Gibson

Karl-Heinz Schlemmer

Heinrich Meier

Michael Sperzel

Nigel J Cuthbert

Rolf Henning

Ulrich Nielsch

Hilary P Francis

Gabriele Br&auml;unlich

Phillip J Gardiner

R&uuml;diger Fischer

Elisabeth Perzborn

Klaus Sasse

Friedel Seuter

Klaus-Helmut Mohrs

Bernhard Pelster

Brian T Warren

R Udiger Fischer

Gabriele Br Aunlich

Warren, Brian T

Michael Hammond

Robert N Schut

Stephen R Tudhope

John E Ransohoff

Tudhope Stephen R

Steve Tudhope

John-Edward Butler-Ransohoff

N-(3-benzofuranyl)urea-derivatives are prepared by reacting of 3-amino-substituted benzofuranes with appropriate substituted isocyanates or isothiocyanates. The N(3-benzofuranyl)urea-derivatives can be used as active ingredients in medicaments particularly for the treatment of acute and chronic inflammatory processes.

N-(3-benzofuranyl)urea-derivatives

N-(3-benzofuranyl) urea-derivatives

The invention relates to benzoic acid derivatives being leukotriene antagonists. The compounds therefore are suitable as active ingredients in medicaments particularly in medicaments for the treatment of respiratory diseases.

Leukotriene antagonistic benzoic acid derivatives

Heterocyclylcarbonyl substituted benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives are prepared by reacting appropriately substituted hydroxybenzene butanoic acid esters with heterocyclic ketones. The inventive compounds can be used for the preparation of medicaments, particularly of medicaments for the treatment and prevention of acute and chronic inflammatory processes.

Heterocyclylcarbonyl substituted benzofuranyl- and

6-Amino-benzofuryl- and thienyl-derivatives can be prepared by reacting appropriate amino-substituted benzoyl phenols with appropriate substituted acetophenones and subsequent modification of the substituents. The compounds are useful for the treatment of actual and chronic inflammatory diseases, particularly of the airways and the gastro-intestinal tract.

Amino-benzofuryl-and thienyl-derivatives

The inventive Oxalylamino-benzofuran- and benzothienyl-derivatives are prepared by reacting the appropriate amino substituted benzofuranes and benzothiophenes with oxalic acid derivatives. The inventive compounds are suitable for the prevention and treatment of acute and chronic inflammatory processes, particularly of the airways.

Oxalylamino-benzofuran- and benzothienyl-derivatives

The Benzofuranyl- and -thiophenyl-alkane-carboxylic acid derivatives are prepared Tby cyclisation of hydroxy acetophenones and related compounds or by Wittig-reaction of benzofuranyl aldehydes. The compounds can be used to prepared medicaments.

Benzofuranyl-and-thiophenyl-alkanecarboxyclic acid derivatives

Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The derivatives have a general formula I ##STR1## in which X is --S--,

Aryl alkenoic acid derivatives as leukotriene antagonists

The new substituted alkenoic acid derivatives can be prepared by reacting the appropriate aldehyde with a phosphonium compound. The compounds have leukotriene antagonistic properties and can be incorporated into pharmaceutical compositions.

Substituted alkenoic acid and its derivatives

An alkenoic acid derivative of the formula ##STR1## in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH.sub.2 --, or oxygen or a direct bond,

Alkenoic acid derivatives

The invention relates to 1-heteroaryl-4-aryl-pyrazolin-5-ones, a preparation process and the use in combating diseases, in particular for use as lipoxygenase inhibitors.

1-Heteroaryl-4-aryl-pyrazolin-5-ones for use as medicaments

Disclosed are trisubstituted benzene derivatives of the formula ##STR1## wherein B is selected from the group consisting of --NHCOC(CH.sub.3).sub.3, 1,3-oxazolinyl and --CONHR, wherein R is methyl, phenyl, or t-butyl; Y is selected from the group consisting of CO.sub.2 H, CHO, CO.sub.2 R' and COR', wherein R' is a lower alkyl having from 1 to 4 carbon atoms; and A is H or tetrahydropyran. Said compounds are valuable intermediates in the preparation of certain anti-allergic chromone or thiochromone-5-oxamic acid derivatives.

Trisubstituted benzene derivatives and a method for the preparation

Certain 5-substituted chromones and thiochromones and pharmacologically acceptable salts thereof are disclosed. The compounds possess antiallergic properties and are represented by the formula: ##STR1## wherein: X is selected from the group consisting of --O--, --S--, and --SO.sub.2 --;

Anti-allergic chromone- or thiochromone-5-oxamic acid derivatives,

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Marlow Bucks, United Kingdom

Trevor S Abram