Ucb Pharma, S.a.

Trevor Morgan

Verity Margaret Sabin

George Martin Buckley

Rikki Peter Alexander

Alan Findlay Haughan

Helen Tracey Horsley

Richard Jeremy Franklin

Anne Marie Foley

Karen Viviane Lucile Crépy

Pavandeep Singh Aujla

Stephen Robert Mack

Kerry Jenkins

William Mark Jones

Bénédicte Irma Léonce Frédérique Lallemand

Patrick Marie Ghislain Pasau

David Jonathan Phillips

Benjamin Garfield Perry

A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Fused thiazole derivatives as kinase inhibitors

A series of 5,5-dimethyl-5,6-dihydro-1,3-benzothiazol-7(4H)-one and 7,7-dimethyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-c]azepin-4-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted benzofused morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. Formula (I). 

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Trevor Morgan