Commonwealth Scientific and Industrial Research Organisation

Gene Shears Pty. Limited

Clinical Genomics Pty. Ltd.

Trevor John Lockett

Fiona Helen Cameron

Minoo Jalili Moghaddam

Steven Whyard

Philip Hendry

Maxine June McCall

Robert George Whittaker

Peter Laurence Molloy

Lawrence Charles Lapointe

Robert Dunne

Jason Francis Conaty

Graeme P Young

Simon MacEwan Carroll

William J Wilson

Pamela Joan Russell

Rosetta Martiniello-Wilks

Minoo Jalali Moghaddam

Ian Keith Smith

The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the methods of the invention will have use in determining the biological function of genes in arthropods. Methods of pest control of arthropods, and of protecting arthropods against parasites and predators are provided. Transgenic arthropods expressing dsRNA molecules are also provided by the present invention.

Delivery of dsRNA to arthropods

This invention is directed to a class of miniribozymes, capable of hybridizing with a target RNA to be cleaved and exhibiting very high cleavage rates at low Mg concentration. The miniribozymes may be used in vitro or in vivo. They may be used as diagnostic or therapeutic agents.

Miniribozymes active at low magnesium ion concentrations

This invention is directed to improved catalytic compounds, minizymes and miniribozymes, capable of hybridizing with a target RNA to be cleaved. The minizymes and miniribozymes and compositions of the present invention may be used in vitro or in vivo. They may be used as diagnostic or therapeutic agents.

Optimized minizymes and miniribozymes and uses thereof

The present invention provides a method for introducing nucleic acids into cells. The method involves exposing the cells to a compound having the formula ##STR1## in which: w is a nucleic acid

Composition and method for delivery of nucleic acids

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Denistone, Australia

Trevor John Lockett