Novartis Ag

Trevor John Howe

Gurdip Bhalay

Darren Mark Le Grand

Clive McCarthy

Thomas Storz

Andrew Dunstan

Angela Glen

Compounds of formula I in free or salt form, wherein T, X, Y, U, R, R, m, n and p have the meanings as indicated in the specification, are useful for treating conditions mediated by CCR3. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Pyrrolidine derivatives acting as CCR3-receptor antagonists

Compounds of formula (I) in free or salt form, where Aris phenyl substituted by one or more substituents selected from halogen, cyano, nitro, and C&#x2013;C-alkyl optionally substituted by cyano or halogen, Aris phenyl optionally which is unsubstituted or substituted by one or more substituents selected from halogen, cyano, hydroxy, nitro, C&#x2013;C-alkyl, C&#x2013;C-haloalkyl, C&#x2013;C-alkoxy or C&#x2013;C-alkoxycarbonyl, Ris C&#x2013;C-alkyl substituted by hydroxy, C&#x2013;C-alkoxy, acyloxy, &#x2014;N(R)R, halogen, carboxy, C&#x2013;C-alkoxycarbonyl, phenyl-C&#x2013;C-alkoxycarbonyl, &#x2014;CON(R)Ror by a monovalent cyclic organic group, Rand R?3are each independently hydrogen or C&#x2013;C-alkyl, or Ris hydrogen and Ris acyl or SOR, or Rand Rtogether with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, Rand Rare each independently hydrogen, C&#x2013;C-alkyl optionally substituted by hydroxy or phenyl, or phenyl optionally substituted by C&#x2013;C-alkyl, halogen, cyano or C&#x2013;C-alkoxy, or Rand Rtogether with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R?6is C&#x2013;C-alkyl, C&#x2013;C-haloalkyl, or phenyl optionally substituted by C&#x2013;C-alkyl, and n is 1, 2, 3 or 4. The compounds are useful as pharmaceuticals.

N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as CCR33 receptor antagonists

Piperidine compounds for use as ccr-3 inhibitors

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Horsham, United Kingdom

Trevor John Howe