Lg Life Sciences, Limited

Sb Pharmco Puerto Rico Inc. of the United States Corporation Company

Trevor John Grinter

Simon Howie

Clemens Michael Helmut Brechtelsbauer

Richard Neville Saunders

Stephen Thomas Carpenter

Youngwoon Kwon

Yeongdae Kim

Dongchul Lee

Michael Anthony Harris

François Xavier Ricard

The invention provides a process for the production of a compound of formula (I): wherein Pand P, which may be the same or different, are amino protecting groups, which comprises protection of a compound of formula (II) in solution phase continuous operation mode. This confers advantages over batch mode operation. The process is usually conducted in reaction equipment adapted for use in continuous processing mode, for example comprising one or more static mixers or a plug flow reactor. Preferably, the plug flow reactor comprises a jacketed tubular reactor fitted inside with internal mixing elements which continually split and remix the reaction streams promoting mass and heat transfer, whereby a uniform plug flow profile with turbulent fluid flow is achieved. The invention also provides a process for production of the antibacterial compound gemifloxacin or a pharmaceutically acceptable salt and/or hydrate thereof, comprising converting a compound of formula (I). The invention also provides a process for the production of a compound of formula (VIIIa) 

Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof

Chemical intermediates which are of use in the production of quinolone carboxylic acid derivatives having antibacterial activity.

Intermediates for the production of quinolone carboxylic acid derivatives

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Tonbridge, United Kingdom

Trevor John Grinter