Collette Nv

Phoqus Pharmaceuticals Limited

Phoqus Limited

Gea Process Engineering Limited

J&m Analytik Ag

Other

Niro A/s

Gea Niro Gmbh

Gea Process Engineering (nps) Ltd

Gea Process Engineering Nv

Gea Pharma Systems Nv

Trevor Gordon Page

Michel Simon Waldron

Linda Ann Reeves

John E Hogan

Ove Emil Hansen

Joachim Mannhardt

John Nicholas Staniforth

Jurgen Boeckx

Martin Koch

John N Stannforth

John N Stantiforth

Tomas Vermeire

A method for continuous production of tablets, including providing a contained module comprising at least two inlets, at least one mixing unit, at least one analytical sensor, a tablet press, and at least one outlet for tablets, feeding an active pharmaceutical ingredient (API) to one of the at least two inlets, feeding an excipient to the other of the at least two inlets, mixing the material stream comprising the API and the excipient in the at least one mixing unit, measuring parameters of the contents of the material stream with the at least one analytical sensor upstream of the tablet press, controlling the two inlets and/or the mixing unit in response to the parameters measured, continuously supplying the tablet press with the material stream, controlling the speed of the tablet press in response to the parameters measured upstream of the tablet press, and discharging tablets at the at least one outlet.

Tablet production module and method for continuous production of tablets

The contained module () comprises inlets for an active pharmaceutical ingredient (API) and for an excipient. The inlets are in fluid communication with at least one mixing unit (), and the outlet of the tablet press () is in fluid communication with the releasable outlet port for tablets. The material stream comprising the API and the excipient is mixed in the mixing units. During operation parameters of the contents of the material stream are measured with one or more analytical sensors upstream of the tablet press. The speed of the tablet press is controlled in response to the parameters measured upstream of the tablet press. The finished tablets are discharged at an outlet of the tablet press ().

A continuous granulator comprises a longitudinal granulation chamber having a first end with an inlet for powder material and a binder feed port and a second end with an outlet for granulated product. The granulation chamber comprises at least two parallel rotary shafts provided with granulating elements and forming an angle of from 0 to 70 degrees with the vertical. Each granulating element on a shaft comprises at least one lobe having limited extent in the circumferential direction of the shaft and interleaving with a lobe of a granulating element on another shaft. A plurality of such separate granulating elements are distributed from the inlet to the outlet, and successive granulating elements on a shaft are mutually angled.

Continuous granulator and method of continuous granulation of powder material

An apparatus for optical measurement of substance concentrations has at least one transmitter arranged in or on a housing and at least one receiver for optical radiation, and a deflection device, which is at a distance from the at least one transmitter and the at least one receiver and is arranged within the substance when the apparatus is being used correctly, for deflection of the optical radiation from the at least one transmitter to the at least one receiver. The distance between the deflection device and the at least one transmitter and/or the at least one receiver can be varied by means of an adjusting device.

Apparatus for optical measurement of substance concentrations

A continuous granulating and drying apparatus comprises a granulator and a fluid bed dryer. The fluid bed dryer comprises at least two separate processing compartments forming part of a common vessel being provided with radially extending partition walls separating the processing compartments from each other. Each processing compartment has a product inlet and a product outlet. The fluid bed dryer comprises a granulated product supply conduit arranged rotatably to selectively communicate with the product inlet of each separate processing compartment, respectively, and a product discharge conduit arranged rotatably to selectively communicate with the product outlet of each separate processing compartment, respectively. The granulator and the fluid bed dryer are closely coupled.

Continuous granulating and drying apparatus

A continuous granulating and drying apparatus includes a granulator and a dryer. Measurement of product and process parameters is carried out by means of measurement units positioned at critical locations in the apparatus.

Continuous granulating and drying apparatus including measurement units

An apparatus for the electromagnetic spectrum or optical analysis of a material. The apparatus comprising a measuring probe having a housing with at least one radiation or light measuring element, a measuring window and with at least one detection element for the analysis. The measuring probe is formed and guided displaceably in the axial direction in such a way that at least part of the housing in which the measuring window is located enters through an opening in which the material to be analyzed is located for the analysis. The at least one measuring window is arranged in at least one subregion of the circumferential wall of the housing. A sealing cap is located between a front end face of the housing and the measuring window arranged in the circumferential wall and consequently covers the opening in a retracted position of the measuring probe.

Apparatus for the electromagnetic spectrum or optical analysis, in particular photometric, spectrophotometric or image analysis

The invention relates to a method and apparatus for producing substantially monodisperse micro particles mainly of heat sensible material using a carrier gas and a drying gas. Relatively dense micro particles with diameters in the range 1-120 &#x3bc;m with a very narrow span can be obtained.

Method and apparatus for producing micro particles

A fluid bed apparatus module () comprises an outer wall enclosing a processing chamber () and has a lower flange connection () and an upper flange connection (), the lower flange connection being adapted to connection with a flange connection () of a supply of fluidising gas, and the upper flange connection being adapted to connection with a flange connection () of a filter chamber () for gas discharge. At least one partition element () is arranged in the processing chamber, so that at least one elongated channel is formed in the processing chamber, thereby defining a plug-flow area, and at least one substantially continuous product inlet () and at least one substantially continuous product outlet () are arranged in the module. Furthermore, a method comprises changing a first module for a second module in a fluid bed apparatus.

Fluid bed apparatus module and method of changing a first module for a second module in a fluid bed apparatus

An apparatus for analyzing a product to be analyzed which is located in a receptacle provided with a coupling element, in particular for photometric or spectrophotometric analysis of powder, bulk material, granular material and similar, is provided with a docking element for sealing connection to the coupling element, and with a measuring probe which is arranged in a probe housing and is provided with at least one radiation and light measuring element, at least one measuring window, which is arranged in the beam path and is arranged in a wall of the probe housing, and with at least one detection element for the analysis. The probe housing with the measuring probe is designed and guided displaceably in such a way that at least a part of the probe housing in which the measuring window is located can be inserted into the receptacle for the analysis.

Apparatus and method for environmentally isolated analysis

The invention provides apparatus for electrostatically coating a pharmaceutical tablet core with powdered coating material. The apparatus comprises a first rotary drum () on which a core is held in electrical isolation from its surroundings but at a potential differecne to earth by an electrode which contacts the core. The core is carried past a coating station B at which particles of powder having an opposite potential difference to earth are held in a tray (). The surface of the drum is held at the same potential difference to earth as the powder particles. The powder is attracted to the core, and not to the drum, coating the exposed surface of the core. The drum carries the coated core past a fusing station C at which a heater fuses the powder to form a continuous film coating. The core is then turned and transferred onto a second drum (') where the other surface is coated in the same way.

Electrostatic coating

An apparatus and method for locking a gun. The apparatus includes a dummy round configured for insertion into a firing chamber of a gun, a locking component configured for coupling with the dummy round, and an elongated sleeve rotatably coupled with the locking component. The locking component includes a keyed head positioned within a longitudinal channel of the elongated sleeve. The locking component and elongated sleeve are insertable through the discharge end of a gun's barrel. An actuating mechanism, such as a key is insertable through the channel of the elongated sleeve to engage with the keyed head and rotate the locking mechanism relative to the elongated sleeve. Rotation of the locking mechanism effects a friction lock between the locking mechanism and the dummy round.

Powder coating composition for electrostatic coating of pharmaceutical substrates

A method of coating a substrate which is a core for a pharmaceutical dosage form, which comprises electrostatically applying to a surface of the core a powder material comprising active material, the coating material applied constituting a dosage of active material, wherein the powder material includes composite particles, each composite particle comprising two or more components having different physical and/or chemical properties.

Method of electrostatically coating a substrate wherein the substrate is brought to a coating station at which it is held substantially electrically isolated from its surroundings adjacent a source of particulate coating material. The substrate and the coating material are held at a potential difference to each other sufficient to coat the exposed surface of the substrate with particles of coating material.

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Southampton, United Kingdom

Trevor Gordon Page