University of Florida Research Foundation, Incorporated

Aerosol Dynamics Inc.

Trevor Benson Tilly

Chang-Yu Wu

Steven Russel Spielman

Gregory Stephen Lewis

Zhonghui Hugh Fan

Arantzazu Eiguren Fernandez

Xiao Jiang

John Lednicky

An apparatus and method for the delivery and deposition of particles air-liquid-interface (ALI) cell cultures includes a sample inlet coupled to a growth tube having interior walls that are wet. The growth tube is configured to operate at a first temperature along a first length of the tube and a second temperature along a second length positioned between the first length and a growth tube outlet. The apparatus also includes a nozzle plate having a plurality of nozzles. The exposure chamber adapted to hold cell cultures at an air-liquid interface positioned underneath the plurality of nozzles and a temperature regulator adapted to control a temperature of the exposure chamber. The apparatus also includes a controller including instructions operable to cause the controller to maintain a relative humidity within the exposure chamber by controlling at least the second temperature of the growth tube and the temperature of the exposure chamber.

Efficient deposition of nano-sized particles onto cells at an air liquid interface

An apparatus and method are provided for performing detection of microorganisms (e.g., viruses) with high sensitivity. The apparatus and method are well suited for point-of-care (POC) testing in resource-limited regions and are capable of being operated with very little manual intervention and without the need for lab equipment. A variety of viruses can be detected with high sensitivity, including, for example, coronaviruses, Zika virus and flu viruses.

Apparatus and method for performing microorganism detection

Growing community of inventors

Columbus, OH, United States of America

Trevor Benson Tilly