Azitra Inc

Travis Michael Whitfill

Azim Momin Munivar

David R Dodds

Ming-De Deng

Alexander Tikhonov

The present invention provides isolated plasmids, recombinant microorganisms, kits, and methods for the treatment of inflammatory skin disease.

Methods and compositions for treating inflammatory skin disease with recombinant microorganisms

The invention relates to methods for treating or preventing abnormal skin conditions in a human in need thereof, comprising administering a cell culture composition comprising a living culture of bacteria comprising at least one engineered strain that produces a recombinant polypeptide for therapeutic treatment of the abnormal skin condition. The invention also relates to pharmaceutical compositions containing, as the active principle, engineered microorganisms expressing non-vaccinogenic pharmacologically active recombinant therapeutic polypeptides in order to treat or prevent abnormal skin conditions.

Therapeutic treatment of skin disease with recombinant commensal skin microorganisms

Methods and compositions for treating skin disease with recombinant microorganisms

The present disclosure provides, inter alia, engineered microbes expressing recombinant LEKTI domains that are effective to treat or ameliorate the symptoms of Netherton Syndrome. In certain embodiments, compositions, methods, and kits are provided comprising LEKTI domain expressing microbes.

Compositions and methods for treatment of Netherton Syndrome with LEKTI expressing recombinant microbes

The present disclosure provides recombinantbacterium (e.g.) that are dependent on D-alanine for growth. In one aspect, the disclosure features a recombinantbacterium comprising two inactivated alanine racemase genes (&#x394;alr1&#x394;alr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the disclosure features a method of making the recombinantbacterium.

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Dallas, TX, United States of America

Travis Michael Whitfill