Motorola Corporation

Amersham Biosciences Ab

Travis Johnson

Allyson J Beuhler

Charles K Brush

Robert E Lajos

John McGowen

George N Maracas

The present invention provides solid supports (e.g., glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprising one or more reactive sites for attachment to solid supports and polymer hydrogels. The invention further provides novel compositions and methods for the preparation of biomolecules, solid supports, and polymer hydrogels comprising reactive sites. The invention also provides for preparation of crosslinked solid supports, polymer hydrogels, and hydrogel arrays, wherein one or more biomolecules is attached by means of the reactive sites in a photocycloaddition reaction. Advantageously, according to the invention, crosslinking of the hydrogel and attachment of biomolecules can be done in a single step.

Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays

A first sensor (18) for electrically sensing a molecular binding event includes a receptor-supporting element (20) into which a reagent is diffusable, at least one molecular receptor (22) supported by the receptor-supporting element (20), and a first electrode (24) embedded in the receptor-supporting element (20). A second sensor for electrically sensing a molecular binding event includes a receptor-supporting element (130), at least one molecular receptor (132) supported by the receptor-supporting element (130), an electrode (134) coupled to the receptor-supporting element (130), and a porous electrode (136) coupled to the receptor-supporting element (130).

Sensors for electrically sensing binding events for supported molecular

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Chandler, AZ, United States of America

Travis Johnson