Ohio State Innovation Foundation

Other

Travis H Jones

Joseph Mitchell West

Vishwanath V Subramaniam

Vish Subramaniam

Emily Alkandry

Dinesh Ahirwar

Mohd Nasser

Ramesh Ganju

Duxin Sun

Chandan K Sen

Sashwati Roy

Peng Zou

Piya Das Ghatak

Shaurya Prakash

Shomita Steiner

Emily Sequin

Jonathan Song

Deepa Subramaniam

Ayush Garg

Mark Drew

Jessica Ferree

Sarah Bushman

Molly Marie Bennett

Emily Quinn Rosenthal

Brad Smith

Joseph Dean West

Jennifer McFerran Brock

Disclosed herein are devices and methods for measuring the effect of chemokines and electric fields on cell migration. This approach is inherently non-contact and does not require injection of current. For example, disclosed herein is a device for assessing cell migration that comprises a cell migration chamber and an electromagnet positioned to produce a uniform electric field across the length of the chamber. Also disclosed is a method for assaying a cell that involves loading cells into the disclosed device along with a chemokine in an amount to produce a chemokine gradient, activating the electromagnet to produce an electric field across the cell migration chamber, and imaging the cells to measure the dual effect of the chemokine and the electric field on the cells.

Microfluidic bi-directional migration assay

Antimicrobial dressings for prevention and mitigation of biofilm and bacterial infection by an applied electric current are provided. Methods of making the dressings and methods of applying an electric current to promote the wound healing process are also disclosed.

Antimicrobial wound care dressing

A non-invasive, continuous, and direct system for detecting the presence of malaria parasites that exploits the paramagnetic properties of hemozoin in red blood cells. An electromagnetic probe (EM probe) is comprised of a dual coaxial coil used to detect iron oxide particles by using sensitive lock-in amplification of detector voltage or phase shift.

Non-invasive method for detecting a deadly form of malaria

An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell lines.

Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells

Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens.

Electromagnetic system and method

Growing community of inventors

West Chester, OH, United States of America

Travis H Jones