Other

University of Florida Research Foundation Inc

Washington State University

United States of America As Represented by the Secretary of the Air Force

The United States of America As Represented by the United States

The United States of America As Represented by the Secretary of

Proscience Corporation

Travis C McGuire

William C Davis

Terry F McElwain

Lance E Perryman

Anthony F Barbet

Guy H Palmer

Douglas P Jasmer

Michael John Burridge

Roman Reddy Ganta

Suman M Mahan

Arthur Rick Alleman

Michael V Bowie

Fred R Rurangirwa

Donald P Knowles, Jr

Michael W Riggs

Annie L Moreland

Will L Goff

William M Whitmire

Bigboy H Simbi

D Scott Adams

Aceme Nyika

Stephen A Hines

David W Reduker

David Stiller

David W Reduker, Deceased

DNA sequences encoding epitopes to which sporozoite-neutralizing antibodies are directed are provided. Recombinant proteins and synthetic peptides containing epitopes for inducing an antigenic response are described.

Neutralization-sensitive epitopes of Cryptosporidium parvum

Described are nucleic acid vaccines containing genes to protect animals or humans against rickettsial diseases. Also described are polypeptides and methods of using these polypeptides to detect antibodies to pathogens.

Nucleic acid vaccines against rickettsial diseases and methods of use

DNA sequences encoding epitopes to which sporozoite-neutralizing antibodies are directed are provided. Recombinant proteins and synthetic peptides containing,epitopes for inducing, an antigenic response are described.

Described are nucleric acid vaccines containing genes to protect animals or humans against,. Also described are polypeptides and methods of using these polypeptides to detect antibodies to pathogens.

Nucleic acid vaccines for ehrlichia chaffeensis and methods of use

The subject invention concerns the use of the conserved,major surface protein 5 gene and gene product and monoclonal antibody ANAF16C1 for the identification of animals persistently infected with Anaplasma species.

Serological identification of cattle, sheep or goats infected with anaplasma species

The subject invention concerns the use of monoclonal antibody ANAF16C1 and Anaplasma species major surface protein-5 in the competitive inhibition format for the serological identification of animals infected with Anaplasma species.

Serological identification of cattle, sheep or goats infected with

A purified antigenic surface protein of Anaplasma marginale has been identified, and is capable of inducing immune responses in ruminants which neutralizes virulent Anaplasma marginale. The antigenic surface protein has a molecular weight of about 105,000 daltons, and can be purified by an immunoaffinity chromatography process. The antigen has further utility in diagnostic tests for anaplasmosis. It can be synthesized by polypeptide procedures or by genetic engineering. DNA and amino acid sequences have been developed for the antigen according to this invention. The antigen is useful as a vaccine component for protecting mammals against infection by Anaplasma marginale and may be useful for rickettsial organisms other than Anaplasma marginale.

Immunogenic anaplasma marginale surface antigens, compositions, and

The subject invention concerns the identification of novel merozoite surface proteins of Babesia bovis. Also disclosed are monoclonal antibodies to these proteins as well as genes which encode for the proteins. The invention further concerns the use of the novel proteins, recombinant DNA clones, and monoclonal antibodies in the detection, treatment, and prophylaxis of babesiosis.

Cloned Babesia DNA

Antigenic surface proteins from the intraerythrocytic merozoite stage of Babesia bigemina have been isolated using cell fusions and monoclonal antibodies produced thereby. The gene encoding a 58 kD surface protein has been identified and the DNA sequence determined and compared with sequences of other known merozoite proteins. Immunization of mammals, such as bovines, with purified isolates induces an immunological response that is effective to reduce pathological effects of babesiosis induced by Babesia bigemina. Diagnostic kits using monoclonal antibodies and antigenic surface proteins of Babesia bigemina are also disclosed.

Immunization against babesiosis using purified surface antigens of

Antigenic surface proteins from the intraerythrocytic merozoite stage of Babesia bigemina have been isolated using cell fusions and monoclonal antibodies produced thereby. Immunization of mammals, such as bovines, with purified isolates induces an immunological response that is effective to reduce pathological effects of babesiosis induced by Babesia bigemina. Diagnostic kits using monoclonal antibodies and antigenic surface proteins of Babesia bigemina are also disclosed.

Immunization against Babesiosis using purified merozoite surface

Cloning of the Babesia bovis 60 KD antigen

The present invention relates to (1) an enzyme-linked immunosorbent assay (ELISA) for detection in milk of antibodies of any isotype which are specific for Staphylococcus aureus proteins in molecular weights ranging from 14,000 to 26,000 daltons, (2) a process for production and purification of the proteins, (3) a method of performing the ELISA utilizing the proteins (4) use of the ELISA for detection of intramammary infection by S. aureus, (5) preparation of monoclonal and polyclonal antibodies against the selected fractions, (6) use of such antibodies of purification of infection specfic antigens, and (7) use of the antibodies in an ELISA for antibodies produced in an individual in response to infection by S. aureus.

Growing community of inventors

Pullman, WA, United States of America

Travis C McGuire